, Volume 74, Issue 2, pp 293–300 | Cite as

Insulin-like immunoreactivity in the human brain

A preliminary report
  • A. Dorn
  • H. G. Bernstein
  • A. Rinne
  • H.-J. Hahn
  • M. Ziegler


The localization and regional distribution of insulin-like immunoreactivity (IRI) was studied in human brain autopsy material using the indirect immunofluorescence technique. A positive reaction for IRI could be observed in many neurons of the hypothalamus, the hippocampus, corpus amygdaloideum, medulla oblongata (especially within the nuclei of cranial nerves IX, X and XII), and the cerebral cortex, whereas the cerebellar cortex was lacking in immunohistochemically detectable insulin-like material. No nerve fibres containing polypeptides could be revealed. Additionally, the inuslin content of various brain regions was estimated by radioimmunosassay. Insulin concentrations in human nervous tissue were found to be elevated in comparison to blood plasma levels.


Human Brain Nerve Fibre Blood Plasma Cranial Nerve Insulin Concentration 
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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • A. Dorn
    • 1
  • H. G. Bernstein
    • 1
  • A. Rinne
    • 2
  • H.-J. Hahn
    • 3
  • M. Ziegler
    • 3
  1. 1.Institute of Anatomy and BiologyMedical Academy MagdeburgMagdeburg
  2. 2.Institute of PathologyUniversity of OuluOulu 22Finland
  3. 3.Central Institute of Diabetes “Gerhardt Katsch”Karlsburg

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