Summary
In this paper investigations concerning the relation between variability of chromosome number and variability of DNA content within the cells of a tumour stemline are reported. A highly heteroploid human tumour cell line was used, which was derived from a chondrosarcoma.
Flow cytometrical and scanning cytophotometrical measurements confirmed the heteroploid nature of the original cell line and of several subclones. Measurement of the DNA content per metaphase showed a linear relation between chromosome number and DNA content of heteroploid cells. This finding is discussed with regard to its implications for the mechanism of heteroploidy in tumour cells.
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Bosman, F.T., Groen, F.C.A. & van der Ploeg, M. DNA content and chromosome number of a heteroploid human tumour cell line. Histochemistry 60, 181–188 (1979). https://doi.org/10.1007/BF00495753
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DOI: https://doi.org/10.1007/BF00495753