Abstract
Seven commercial inhibitors of sterol biosynthesis were tested for their effect upon vegetative growth and sexuality in Pythium acanthicum and Zygorhynchus moelleri. Five compounds (SKF 525, Chlorpropamide, Tolbutamide, Benzmalacene, AY 9944) inhibited both growth and sexuality of both fungi and two (SKF 7732 and SKF 7997) were ineffective. Pythium was more sensitive to the activity of the inhibitors than was Zygorhynchus. None of the compounds tested inhibited sexuality without similarly reducing vegetative growth.
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Chappel, C., J. Dubue, D. Dvorink, M. Givner, L. Hurber, M. Kraul, K. Voith & R. Gaudey.1964. An inhibitor of cholesterol biosynthesis. Nature 201: 498.
Child, J.J., G. Defago & R.H. Haskins. 1969. The influence of carbon and nitrogen nutrition on growth and sterol-induced sexuality of Pythium sp. PRL 2142. Mycologia LXI 1096–1105.
Dick, F.C., S.M. Greenberg, J.F. Herndon, M. Jones & E.J. Van Loon. 1960. Hypocholesterine effect of ß-diethyl amino ethyl diphenylpropyl acetate hydrochloride (SKF 525-A) in the dog. Proc. Soc. Expl. Biol. Acad. 104:523–526.
Elliott, C.G. 1969. Effects of inhibitors of sterol synthesis on growth of Sordaria and Phytophthora. J.Gen.Microbiol. 56: 331–343.
Haskins, R.H., A.P. Tulloch & R.G. Micetich. 1964. Sterols and the stimulation of sexual reproduction of a species of Pythium. Can. J. Microbiol. 10: 187–195.
Hendrix, J.W. 1965. Influence of sterols on growth and reproduction of Pythium and Phytophthora spp. Phytopathology 55: 790–797.
Hendrix, J.W. 1970. Sterols in growth and reproduction of fungi. Ann. Review of Phytopathology 8: 111–130.
Holmes, W.L. & N.W. Di Tullo. 1962. Inhibitors of cholesterol biosynthesis which act at or beyond the mevalonic acid stage. Am. J. Chem. Nutr. 10: 310.
Horlick, T. 1966. Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat. J. Lipid Res. 7:116.
Nelson, R.R., D. Huisingh & R.K. Webster. 1967. Sexual differentiation in Cochliobolus carbonum as influenced by inhibitors and repair of sterol biosynthesis. Phytopathology 57: 1081.
Schlosser, E. & D. Gottlieb. 1968. The effect of sterols on the metabolism of Pythium species. Archiv. für Mikrobiologie 61: 246–253.
Sietsma, J.H. & R.H. Haskins. 1968. The incorporation of cholesterol by Pythium sp. PRL 2142, and some of its effects on cell metabolism. Can. J. Biochem. 46: 813–181.
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NRCC No. 15402
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Child, J.J., Haskins, R.H. Effect of inhibitors of sterol biosynthesis on growth and sexuality of pythium and zygorhynchus. Mycopathologia 59, 91–93 (1976). https://doi.org/10.1007/BF00493560
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DOI: https://doi.org/10.1007/BF00493560