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Macrophage subsets in different types of urticaria

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Summary

Biopsy specimens from lesional and uninvolved skin of nine patients with delayed pressure urticaria, three patients with acute urticaria, six patients with chronic recurrent urticaria, and four patients with urticaria pigmentosa were analyzed by routine histology and by immunochemistry for their reactivity with monoclonal antibodies to three different subsets of macrophages. Skin from 12 healthy volunteers served as control. Uninvolved skin of patients did not differ from that of healthy volunteers. An antibody against activated macrophages (27E10) was reactive to a marked extent with macrophages in wheals of pressure urticaria, more variably in acute and chronic urticaria, and practically not at all in urticaria pigmentosa. Antibodies with specificities for macrophages in healing (RM3/1) and normal (25F9) tissue reacted more markedly in all but pressure urticaria lesions, compared with normal skin. These findings indicate an active involvement of inflammatory macrophages in whealing reactions while these cells play apparently no role in cutaneous mast cell proliferation (urticaria pigmentosa).

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References

  1. Czarnetzki BM (1986) Urticaria. Springer, Berlin Heidelberg New York

    Google Scholar 

  2. Czarnetzki BM (1987) Mechanisms and mediators in urticaria. Semin Dermatol 6:272–285

    Google Scholar 

  3. Czarnetzki BM, Fidgor CG, Kolde G, Vroom T, Aalberse R, de Vries JE (1984) Development of human connective tissue mast cells from purified blood monocytes. Immunology 51:549–554

    Google Scholar 

  4. Czarnetzki BM, Meentken J, Rosenbach T, Pokropp A (1984) Clinical, pharmacological and immunological aspects of delayed pressure urticaria. Br J Dermatol 111:315–323

    Google Scholar 

  5. Czarnetzki BM, Meentken J, Kolde G, Bröcker EB (1985) Morphology of the cellular infiltrate in delayed pressure urticaria. J Am Acad Dermatol 12:253–259

    Google Scholar 

  6. Elias J, Boss E, Kaplan AP (1986) Studies of the cellular infiltrate of chronic iodopathic urticaria: prominence of T-lymphocytes, monocytes, and mast cells. J Allergy Clin Immunol 78:914–918

    Google Scholar 

  7. Martin PJ, Andrew RK, Robin MB (1981) A microscopic study of inflammatory reactions in human skin induced by histamine and compound 48/80. J Invest Dermatol 78:406–413

    Google Scholar 

  8. Mekori YA, Giorno RC, Anderson P, Kohler PF (1983) Lymphocyte subpopulations in the skin of a patient with chronic urticaria. J Allergy Clin Immunol 72:681–684

    Google Scholar 

  9. Monroe EW, Schulz CI, Maize JC, Jordon RE (1981) Vasculitis in chronic urticaria. An immunopathological study. J Invest Dermatol 76:103–107

    Google Scholar 

  10. Natbony SF, Phillips ME, Elias JM, Godrey HP, Kaplan AP (1983) Histologic studies of chronic idiopathic urticaria. J Allergy Clin Immunol 71:177–183

    Google Scholar 

  11. Phanuphak P, Kohler PF, Stanford RE, Schocket AL, Carr RI, Claman HN (1980) Vasculitis in chronic urticaria. J Allergy Clin Immunol 65:436–444

    Google Scholar 

  12. Soter NA, Austen KF, Gigli I (1974) Urticaria and arthralgias as a manifestation of necrotizing angiitis (vasculitis). J Invest Dermatol 63:485–490

    Google Scholar 

  13. Topoll HH, Zwadlo G, Lange DE, Sorg C (1987) Analyse des entzündlichen Infiltrates verschiedener Entzündungsstadien der marginalen Gingiva mittels monoklonaler Antikörper. Dtsch ZahnÄrztl Z 42:467–470

    Google Scholar 

  14. Winkelmann RK, Black AK, Dover J, Greaves MW (1986) Pressure urticaria — histopathological study. Clin Exp Dermatol 11:139–147

    Google Scholar 

  15. Zwadlo G, Bröcker EB, Bassewitz DB, Feige U, Sorg C (1985) A monoclonal antibody to a differentiation antigen present on mature human macrophages and absent from monocytes. J Immunol 134:1487–1492

    Google Scholar 

  16. Zwadlo G, Schlegel R, Sorg C (1986) A monoclonal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues. J Immunol 137:512–518

    Google Scholar 

  17. Zwadlo G, Voegeli R, Schulze Osthoff K, Sorg C (1987) A monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process. Exp Cell Biol 55:295–304

    Google Scholar 

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Authors and Affiliations

  1. Departments of Clinical and Experimental Dermatology, University Clinics, Münster, FRG

    B. M. Czarnetzki, G. Zwadlo-Klarwasser, E. -B. Bröcker & C. Sorg

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  1. B. M. Czarnetzki
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  2. G. Zwadlo-Klarwasser
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  3. E. -B. Bröcker
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  4. C. Sorg
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Czarnetzki, B.M., Zwadlo-Klarwasser, G., Bröcker, E.B. et al. Macrophage subsets in different types of urticaria. Arch Dermatol Res 282, 93–97 (1990). https://doi.org/10.1007/BF00493465

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  • DOI: https://doi.org/10.1007/BF00493465

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