, Volume 42, Issue 4, pp 351–358 | Cite as

Immunoelectronmicroscopic localization of phenylethanolamine-N-methyltransferase in the bovine adrenal medulla

  • I. Nagatsu
  • Y. Kondo


The subcellular localization of phenylethanolamine-N-methyltransferase (PNMT) in the bovine adrenal medulla has been examined by a peroxidase-labelled immunoelectronmicroscopic method. The enzyme is localized in the ground substance of the epinephrine-containing cells, but not in the norepinephrine-containing cells. PNMT is not shown in the nucleus, mitochondria, Golgi complex, ribosomes and norepinephrine granules. There are some observations which indicate that PNMT might be also localized in epinephrine granules.


Public Health Norepinephrine Epinephrine Subcellular Localization Golgi Complex 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • I. Nagatsu
    • 1
  • Y. Kondo
    • 1
  1. 1.Laboratory of Molecular Biology, Institute for Medical Sciences, School of MedicineFujita-Gakuen UniversityToyoakeJapan

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