Skip to main content
SpringerLink
Log in

Permanent neonatal diabetes mellitus: A case report with plasma insulin studies

  • Published:
Zeitschrift für Kinderheilkunde Aims and scope Submit manuscript

Abstract

The 11th case of permanent neonatal diabetes mellitus appearing during the first month of life is reported. A critical review of the literature is also presented.

The permanence of diabetes is demonstrated by the duration of insulin therapy still necessary after 30 months.

Insulin-stimulation tests have been performed some for the first time in such a young diabetic. They have shown a nearly total failure in β-cell response, only very high doses of glucagon provoking a moderate insulin secretion.

The absence of acetonuria is discussed. It can perhaps be explained by the hyperglycemia which, by a mass effect, brings about cellular glucose penetration and this stops liberation of Nefa's from adipose tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ambard, Merklen, Schmid, Wolf, Arnovitch: Diabète grave chez une femme enceinte et diabète congénital chez l'enfant. Bull. mém. Soc. Hôp. Paris 41, 547 (1925)

    Google Scholar 

  • Arey, S. L.: Transient diabetes in infancy. Pediatrics 11, 140 (1953)

    Google Scholar 

  • Assevero, V. L., Moss, J.: Diabetes mellitus in infancy. J. Pediat. 53, 227 (1958)

    Google Scholar 

  • Babinet, J. M., Labrune, B., Lejeune, C., Paillerets, F.: Diabète néonatal vrai. Ann. Pédiat. 21, 463 (1973)

    Google Scholar 

  • Boon, W. H.: Diabetes mellitus in a 2-month-old chinese baby. Arch. Dis. Childh. 32, 197 (1957)

    Google Scholar 

  • Brugsch, H.: Diabetes mellitus im Säuglingsalter. Z. ärztl. Fortbild. 51, 439 (1962)

    Google Scholar 

  • Burland, W. L.: Diabetes mellitus syndrome in the newborn infant. J. Pediat. 65, 122 (1964)

    Google Scholar 

  • Chambers, D. C., Watt, P., Smith, K. A.: Diabetes mellitus in a sixty-seven-day-old infant. J. Amer. med. Ass. 169, 970 (1957)

    Google Scholar 

  • Chance, G. W., Bower, B. D.: Hypoglycemia and temporary hyperglycemia in infants of low birth weight for maturity. Arch. Dis. Childh. 41, 279 (1966)

    Google Scholar 

  • Chieffi, A.: Über den sog. transitorischen Diabetes des Neugeborenen und seine möglichen Beziehungen zu einem hypoglykämischen Zustand der Mutter. Athena (Roma) 21, 1 (1955)

    Google Scholar 

  • Coffey, J. D., Womack, N. C.: Transient neonatal diabetes mellitus in half sisters. Amer. J. Dis. Childh. 113, 480 (1967)

    Google Scholar 

  • Cornblath, M., Schwartz, R.: Disorders of carbohydrate metabolism in infancy. Major Problems in Clin. Pediat. 3, 105 (1966)

    Google Scholar 

  • Cuno, F.: cited by Schwartzman et al.

  • Delange, F., Loeb, H.: Le diabète du nourrisson. Acta Paediat. belg. 20, 79 (1966)

    Google Scholar 

  • Devine, J.: A case of diabetes mellitus in a young infant. Arch. Dis. Childh. 13, 189 (1938)

    Google Scholar 

  • Dourov, N., Buyl-Strouvens, A. M.: Agenesie du pancréas. Observation anatomoclinique d'un cas de diabète sucré, avec stéatorrhée et hypotrophie, chez un nouveau-né. Arch. franç. Péd. 26, 641 (1969)

    Google Scholar 

  • Engelson, G., Zetterquist, P.: Congenital diabetes mellitus and neonatal pseudodiabetes mellitus. Arch. Dis. Childh. 32, 193 (1969)

    Google Scholar 

  • Feldmann, I.: Diabetes intrauterine. Zbl. allg. Path. Anat. 42, 435 (1928)

    Google Scholar 

  • Ferguson, A. W., Milner, R. D. G.: Transient neonatal diabetes mellitus in sibs. Arch. Dis. Childh. 45, 80 (1970)

    Google Scholar 

  • Ferguson, I. C.: Neonatal hyperglycemia: a case report with plasma insulin studies. Arch. Dis. Childh. 42, 509 (1967)

    Google Scholar 

  • François, R., Hermier, M., Jarlot, B., Laubeuf, J. C., David, C., Pouillaude, J. M.: Le diabète de la première année. Arch. franç. Pédiat. 29, 941 (1972)

    Google Scholar 

  • Gairdner, D., Gandy, G.: Permanent diabetes mellitus in a neonate. J. Pediat. 80, 334 (1972)

    Google Scholar 

  • Gans, G.: Diabetes mellitus in an infant aged 39 days. Proc. Soc. Med. 47, 132 (1954)

    Google Scholar 

  • Gentz, J. C. H., Cornblath, M.: Transient diabetes of the newborn. Advanc. Pediat. 16, 345 (1969)

    Google Scholar 

  • Gerrard, J. W., Chin, W.: The syndrome of transient diabetes. J. Pediat. 61, 89 (1962)

    Google Scholar 

  • Geefhysen, J.: Temporary idiopathic neonatal hyperglycemia. J. Pediat. 38, 1009 (1966)

    Google Scholar 

  • Gilly, R., Charvet, F., Dutruge, J., Noiret, A., Dubois, Y.: Hyperglycémie néonatale transitoire avec coma hyperosmolaire. Pédiatrie 26, 580 (1971)

    Google Scholar 

  • Grenwood, R. G., Traisman, H. S.: Permanent diabetes mellitus in a neonate. J. Pediat. 79, 296 (1971)

    Google Scholar 

  • Guest, G. M.: Infantile diabetes mellitus: Three cases in successive siblings, two with onset at three months of age and one at nine days of age. Amer. J. Dis. Child. 75, 461 (1948)

    Google Scholar 

  • Hager, H., Herbst, R.: Das transitorische Diabetes mellitus-Syndrom des Neugeborenen, ein Krankheitsbild sui generis. Z. Kinderheilk. 95, 324 (1966)

    Google Scholar 

  • Hesse, H.: Angeborener Diabetes mellitus bei zwei Vettern. Kinderärztl. Prax. 31, 333 (1963)

    Google Scholar 

  • Hickish, G.: Neonatal diabetes. Brit. med. J. 1956 I, 95

  • Hofman-Bang, E.: Diabetic coma in a three weeks old infant. Acta Paediat. 43, 393 (1964)

    Google Scholar 

  • Holland, C. L., Holland, E. A.: Diabetes mellitus in infancy. W. Virginia med. J. 32, 407 (1930)

    Google Scholar 

  • Hutchinson, J. H., Keay, A. J., Kerr, M. M.: Congenital temporary diabetes mellitus. Brit. med. 1962 II, 436

  • Jeune, M., Mme. Riedweg: Syndrome diabétique transitoire chez un nouveau-né. Pédiatrie 15, 63 (1960)

    Google Scholar 

  • Kasi, A. M.: Neonatal diabetes mellitus. Brit. med. J. 1964 II, 1137

    Google Scholar 

  • Keidan, S. E.: Transient diabetes in infancy. Arch. Dis. Childh. 30, 291 (1953)

    Google Scholar 

  • Kitselle, J. F., cited by Schwartzman

  • Kloss, J. C.: Transient diabetes in the newborn. Report of the 20 th case and review of pediatric literature. Clin. Pediat. 6, 303 (1967)

    Google Scholar 

  • Kouvalainen, K., Väänänen, J., Hiekkala, H.: Neonatal pseudodiabetes mellitus. Report of a case. Ann. Paediat. Fenn. 7, 242 (1961)

    Google Scholar 

  • Lamy, M., Jammet, M. L., Lestradet, H., Sitbon, C.: Diabète chez un enfant de deux mois et demi. Considérations sur le pronostic et sur le traitement. Arch. franç. Pédiat. 18, 1059 (1961)

    Google Scholar 

  • Langstein, L.: cited by Schwartzman

  • Lawrence, R. D., Mac Cance, R. A.: Gangrene in an infant associated with temporary diabetes. Arch. Dis. Childh. 6, 343 (1931)

    Google Scholar 

  • Leclercq, R., Copinschi G., Franckson, J. R. M.: Le dosage par compétition du cortisol plasmatique. Modification de la méthode de Murphy. Rev. franç. clin. Biol. 14, 815 (1969)

    Google Scholar 

  • Le Dune, M. A.: Insulin studies in temporary neonatal hyperglycemia. Arch. Dis. Childh. 46, 392 (1971)

    Google Scholar 

  • Lewis, E., Eisenberg, H.: Diabetes mellitus neonatorum. Amer. J. Dis. Child. 49, 408 (1935)

    Google Scholar 

  • Lewis, S. R., Mortimer, P. E.: Idiopathic neonatal hyperglycemia. Arch. Dis. Childh. 39, 618 (1964)

    Google Scholar 

  • Limper, M. A., Miller, A. J.: Diabetes mellitus with extensive gangrene in early infancy. Amer. J. Dis. Child. 50, 1216 (1935)

    Google Scholar 

  • Meyer, B., Nezelof, Ch., Mme Lemoine, Charlas, J., Caille, B., Vialatte, J.: A propos de deux cas de diabète néonatal. Ann. Pédiat. 17, 569 (1971)

    Google Scholar 

  • Milner, R. D. G., Ferguson, W. A., Naiou, S. M.: Aetiology of transient neonatal diabetes. Arch. Dis. Childh. 46, 724 (1971)

    Google Scholar 

  • Morais, T., Demers, P. P.: Le diabète néonatal. Laval méd. 38, 337 (1967)

    Google Scholar 

  • Moschos, A., Nicolopoulos, D.: Permanent neonatal diabetes mellitus. Clin. Pediat. 11, 661 (1972)

    Google Scholar 

  • Nawrocka-Kanska, B.: Diabetes syndrome in the course of intracranial bleeding in newborn. Pediat. pol. 27, 1067 (1952)

    Google Scholar 

  • Nivelon, J. L., Badinaud, P., Fau, M., Cotte, M. P., Ruitton-Ugliengo, A., Bethenod, M.: Hyperglycémie néonatale transitoire et idiopathique Observation avec étude de l'insuline plasmatique. Pédiatrie 25, 887 (1970)

    Google Scholar 

  • Ooms, H. A.: Emploi des insulines radioidées comme traceurs en biologie. Thèse d'agrégation de l'Enseignement Supérieur, Université Libre de Bruxelles 1972

  • Osborne, G. R.: Congenital diabetes. Arch. Dis. Childh. 40, 332 (1965)

    Google Scholar 

  • Pellet, H., Moreau, P., François, R.: Le diabète du nourrisson. Rev. Pédiat. II, 109 (1966)

    Google Scholar 

  • Perelman, R., Lestradet, H.: Diabète néonatal. Ann. Pédiat. 40 283 (1964)

    Google Scholar 

  • Ramsay, W. R.: Glycosuria of newborn treated with insulin. Transient diabetes in an infant of one month of age. Trans. Amer. pediat. Soc. 38, 100 (1926)

    Google Scholar 

  • Schalck, D. S., Parker, M. L.: A sensitive double antibody immunoassay for human growth hormone in plasma. Nature (Lond.) 203, 1141 (1964)

    Google Scholar 

  • Schwartzman, J., Crusius, M. E., Beirne, D. P.: Diabetes mellitus in infants under one year of age. Amer. Dis. Child. 74, 587 (1947)

    Google Scholar 

  • Scheffner, D.: Zentraler geburtstraumatischer transitorischer Diabetes mellitus. Ann. Paediat. (Basel) 197, 243 (1961)

    Google Scholar 

  • Schretter, G., Nevinny, H.: Zur Histopathologie der Zuckerkrankheit bei Neugeborenen und Säuglingen. Arch. Gynäk. 140, 297 und 143, 495 (1930)

    Google Scholar 

  • Soto, A. S.: Syndrome de diabetes transitoria in un lactante de 45 dias de edad. Arch. venez. Pediat. 28, 324 (1965)

    Google Scholar 

  • Strandquist, B.: Infantile glycosuria simulating diabetes. Acta Paediat. 13, 421 (1932)

    Google Scholar 

  • Struwe, Fr. E.: Zur Manifestation des Diabetes mellitus im Kindesalter. Mschr. Kinderheilk. 108, 487 (1960)

    Google Scholar 

  • Sweetnam, W. P., Sykes, C. G. W.: Congenital Diabetes mellitus. Brit. med. J. 1962 II, 671

  • Tjoa, G. T., Denijsbik, H., Shopan, W.: Diabetes mellitus in a 2 months old female infant. Biol. Neonat. (Basel) 13, 113 (1968)

    Google Scholar 

  • Weill, J., Baruch, J., Bergeret, G., Dommerques, J. P., Weisgerber, C.: Le diabète du nouveau-né. Bull. mém. Soc. Hôp. Paris 117, 207 (1966)

    Google Scholar 

  • Willi, H., Muller, F.: Über den transitorischen Diabetes mellitus des Neugeborenen. Helv. paediat. Acta 3, 231 (1968)

    Google Scholar 

  • Wolter, R., Loeb, H., Brunet-Verhougstraeten, N.: Variations du taux de l'hormone de croissance sérique en réponse à l'hypoglycémie chez l'enfant obèse. Rev. méd. Liège 23, 59 (1968)

    Google Scholar 

  • Wylie, M. E. S.: A case of congenital Diabetes. Arch. Dis. Childh. 28, 297 (1953)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Paediatrics and Clinical Chemistry, University of Brussels, Belgium

    H. Dorchy, H. Ooms & H. Loeb

  2. Service de Pédiatrie, Hôpital Universitaire Saint-Pierre, 320, Rue Haute, 1000, Bruxelles, Belgium

    H. Dorchy

Authors
  1. H. Dorchy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Ooms
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Loeb
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dorchy, H., Ooms, H. & Loeb, H. Permanent neonatal diabetes mellitus: A case report with plasma insulin studies. Z. Kinder-Heilk. 118, 271–281 (1975). https://doi.org/10.1007/BF00492333

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00492333

Key words

Search

Navigation