Abstract
Cerebrospinal fluid (CSF) concentration and urinary excretion of cyclic adenosine-3′,5′-monophosphate (cAMP) were measured in children aged from 3 days to 15 years by the protein-binding method of Gilman (1970).
The mean CSF cAMP concentration (22.4±0.6 (S.E.) nmol/l) of 24 “healthy” children tended to be lower (P<0.2) than that of adult patients who revealed no pathological findings on clinical examination. No difference in the results was found between the sexes. High cAMP concentrations were found in CSF of children suffering from cerebellar glioma, hypothalamic precocious puberty, bacterial meningitis, or Cushing's disease.
The urinary excretion of cAMP varied from 0.2 to 5.3 in “healthy” and from 1.3 to 7.6 μmol/24 hrs in diseased children. Two children with pheochromocytoma showed a striking decrease in the rate of urinary excretion of the nucleotide after surgical treatment.
Zusammenfassung
Die Konzentration des cyclischen Adenosin-3′,5′-Monophosphat (cAMP) im Liquor cerebrospinalis und seine Ausscheidung im Urin wurden bei Kindern im Alter von 3 Tagen bis 15 Jahren gemessen.
Der Mittelwert von cAMP im Liquor cerebrospinalis (22,4±0,6 nmol/l) der 24 gesunden Kinder war etwas niedriger als der 13 Erwachsener ohne pathologische klinische Befunde (P<0,2). Es gab keinen Unterschied zwischen Mädchen und Jungen. Hohe cAMP-Werte wurden im Liquor cerebrospinalis der Kinder, die an einem cerebellaren Gliom, einer vorzeitigen hypothalamischen Pubertät, einer bakteriellen Meningitis oder einem Cushing-Syndrom litten, gemessen.
Die Ausscheidung des cAMP war 0,2–5,3 bei gesunden Kindern und 1,3–7,6 μmol/24 Std bei kranken Kindern. 2 Patienten, erkrankt an Phäochromocytom, zeigten eine starke Verminderung der Ausscheidung von cAMP nach der Operation.
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Myllylä, V.V., Heikkinen, E.R., Similä, S. et al. Cerebrospinal fluid concentration and urinary excretion of cyclic adenosine-3′, 5′-monophosphate in various diseases of children. Z. Kinder-Heilk. 118, 259–264 (1975). https://doi.org/10.1007/BF00492331
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DOI: https://doi.org/10.1007/BF00492331