Psychopharmacology

, Volume 65, Issue 3, pp 311–315 | Cite as

Differential effects of methylphenidate and d-amphetamine on stereotyped behavior in the rat

  • Robert Pechnick
  • David S. Janowsky
  • Lewis Judd
Original Investigations

Abstract

Different equimolar doses of d-amphetamine and methylphenidate were compared for their potency in eliciting stereotyped behavior in rats. Although at lower doses d-amphetamine appeared more effective in causing stereotyped gnawing, repetitive body movements, and sniffing, at higher doses methylphenidate at certain times caused a greater incidence of gnawing than did d-amphetamine. Understanding these differences and comparing related biochemical correlates may lead to a better definition of mechanisms underlying psychostimulant effects.

Key words

Methylphenidate d-Amphetamine Stereotyped behavior Gnawing behavior Rats Psychostimulants 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Robert Pechnick
    • 1
  • David S. Janowsky
    • 1
  • Lewis Judd
    • 1
  1. 1.Department of PsychiatryUniversity of California at San Diego, School of MedicineLa JollaUSA

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