Psychopharmacology

, Volume 65, Issue 1, pp 35–40 | Cite as

A characteristic effect of hallucinogens on investigatory responding in rats

  • Mark A. Geyer
  • Roger K. Light
  • Gary J. Rose
  • Lyle R. Petersen
  • David D. Horwitt
  • Lynne M. Adams
  • Richard L. Hawkins
Original Investigations

Abstract

The disruption of the temporal distribution of investigatory responses by rats in a novel hole-board following lysergic acid diethylamide-25 (LSD), as described in a companion paper (Geyer and Light, 1979), was found to be a characteristic effect of a variety of hallucinogens. Similar effects were produced by indoleamine hallucinogens, such as LSD, N,N-dimethyltryptamine, and psilocin, and by phenylethylamine hallucinogens, such as mescaline or 2,5-dimethoxy-4-methylamphetamine (DOM). Congeners of DOM that are inactive in humans had no significant effects. Furthermore, of a variety of other psychoactive drugs tested, only apomorphine produced an effect similar to that of the hallucinogens. These results suggest that a simple behavioral measure of exploration in a hole-board may provide a useful animal model with which to examine the common effects of hallucinogens.

Key words

Hallucinogens Hole-board Exploration Orienting response 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Mark A. Geyer
    • 1
  • Roger K. Light
    • 1
  • Gary J. Rose
    • 1
  • Lyle R. Petersen
    • 1
  • David D. Horwitt
    • 1
  • Lynne M. Adams
    • 1
  • Richard L. Hawkins
    • 1
  1. 1.Department of PsychiatryUCSD School of MedicineLa JollaUSA

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