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Anomalous eosinophil granulocytes in blood and bone marrow: a diagnostic marker for infantile GM1-gangliosidosis?

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Abstract

On routine smears of blood and bone marrow of four patients with GM1 gangliosidosis type I, eosinophil granulocytes were unusually pale and contained faintly stained, unevenly spaced granules some of which were larger than normal and had abnormal ultrastructural appearance. The anomaly may represent a hitherto overlooked but easily obtainable diagnostic marker.

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References

  1. Kline J (1975) The White Cell. Harvard University Press, Cambridge London

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  2. O'Brien JS (1983) The gangliosidoses. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease. McGraw-Hill, New York, pp 831–841

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  3. (Reference list available from the principal author)

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Authors and Affiliations

  1. Department of Pediatrics, University of Zürich, Switzerland

    R. Gitzelmann, S. Adank & B. Steinmann

  2. Institute of Pathology, University of Zürich, Switzerland

    M. A. Spycher

  3. Children's Hospital of St. Gallen, Switzerland

    K. Baerlocher

Authors
  1. R. Gitzelmann
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  2. M. A. Spycher
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  3. S. Adank
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  4. K. Baerlocher
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  5. B. Steinmann
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Gitzelmann, R., Spycher, M.A., Adank, S. et al. Anomalous eosinophil granulocytes in blood and bone marrow: a diagnostic marker for infantile GM1-gangliosidosis?. Eur J Pediatr 144, 82–84 (1985). https://doi.org/10.1007/BF00491934

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  • DOI: https://doi.org/10.1007/BF00491934

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