European Journal of Pediatrics

, Volume 144, Issue 1, pp 49–52 | Cite as

Plasma fibronectin concentrations in healthy and septic infants

  • M. Domula
  • K. Bykowska
  • Z. Wegrzynowicz
  • S. Lopaciuk
  • G. Weißbach
  • M. Kopeé
Original Investigations


The concentration of plasma fibronectin was determined by Laurell's electroimmunoasay [15] in 75 preterm or term newborns within the first 2 days of life, in 97 healthy infants aged from 3 days to 12 months, in 40 septic infants and in 38 healthy adult subjects. The mean fibronectin concentration in citrated plasma of normal adults was 318±84 ml/l. Healthy eutrophic term newborns 1–2 days old had approximately one-third of the fibronectin concentration of adults. There was no significant difference in the values between healthy term and eutrophic preterm newborns or between eutrophic and hypotrophic newborns. The plasma fibronectin increased strongly over the 1st month of life. No significant difference was observed between fibronectin levels in infant boys and girls. The values in septic newborns and septic older infants were significantly lower when compared with those of age-matched healthy controls. It is speculated that this deficiency, because of linkage to fibrin in disseminated intravascular coagulation or due to increased utilisation as a non-specific opsonin and sequestration at sites of tissue injury, may contribute to organ failure in septicaemia.

Key words

Plasma fibronectin Newborn infants Septicaemia 



surface binding


disseminated intravascular coagulation


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. Domula
    • 1
  • K. Bykowska
    • 2
  • Z. Wegrzynowicz
    • 2
  • S. Lopaciuk
    • 2
  • G. Weißbach
    • 1
  • M. Kopeé
    • 3
  1. 1.Paediatric Clinic, Department of MedicineKarl-Marx-UniversityLeipzigGerman Democratic Republic
  2. 2.Department of Internal MedicineInstitute of HematologyWarsawPoland
  3. 3.Department of Radiobiology and Health ProtectionInstitute of Nuclear Chemistry and TechnologyWarsawPoland

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