Summary
In immunocytochemical experiments on human kidney tissue with an antiserum directed against the prosegment of renin, only juvenile granules were clearly labeled. As the concentration of renin increases from protogranules to more mature granules, while the concentration of its prosegment decreases to subthreshold levels, it is assumed that the cleavage of the prosegment, i.e. the activation of renin takes place in juvenile granules parallel to the condensation of the enzyme.
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These studies were supported by the German Research Foundation within the SFB 90 “Cardiovasculäres System”
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Tangner, R., Murakami, K. & Kim, SJ. Renin activation in juvenile secretory granules?. Histochemistry 85, 107–109 (1986). https://doi.org/10.1007/BF00491755
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DOI: https://doi.org/10.1007/BF00491755