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Benzamide action at α2-adrenoceptors modifies catecholamine-induced contraction and relaxation of circular smooth muscle from guinea-pig stomach

  • Hassib A. Sahyoun
  • Brenda Costall
  • Robert J. Naylor
Article

Summary

Dopamine was shown to act on the circular smooth muscle of the stomach body to cause contraction at a yohimbine-sensitive site (α2) and a relaxation at a prazosin-sensitive site (α1). Metoclopramide and tiapride failed to modify either response, failed to antagonise a relaxation to phenylephrine at 1(α1 sites in the same tissue, and failed to modify the contractions caused by dopamine and phenylephrine at an α2-adrenoceptor site in the pyloric sphincter. However, (+)- and (−)-sultopride and (+)-sulpiride antagonised the dopamine-induced contractions of the stomach body indicating an α2-antagonist action. An ability to attenuate the relaxation of this tissue may reflect a displacement of the contraction curve to the right rather than an α2-antagonist action since the response to phenylephrine was not antagonised either in this tissue or in the pyloric sphincter. Within the central nervous system the (−)-enantiomers of sultopride and sulpiride have a highly selective dopamine receptor blocking action. This cotrasts with the present findings in the stomach musculature of a non-stereospecific antagonism at α2-type adrenoceptors.

Key words

Benzamide derivatives Stomach musculature α1-Adrenoceptors α2-adrenoceptors 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Hassib A. Sahyoun
    • 1
  • Brenda Costall
    • 1
  • Robert J. Naylor
    • 1
  1. 1.Postgraduate School of Studies in PharmacologyUniversity of BradfordBradfordUK

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