Summary
Microperoxisomes were identified in the cells of proximal tubules of the kidney and small intestine of mice from 13–19 days old embryos, in suckling period and adult animals. Examination of both tissues after incubation in diaminobenzidine medium revealed anucleoid microperoxisomes closely related to the granular endoplasmie reticulum and occasionally found in close relation to it. The number of microperoxisomes within the cells considerably increases with the advanced stage of differentiation of both studies tissues. In the cells of proximal tubules the changes in shape and size of microperoxisomes are also observed with a higher stage of differentiation. These studies indicate that the formation and augmentation of microperoxisomes passes strictly parallely with the differentiation, i.c. with the ability of cells to perform their specific functions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Beard, M. E., Novikoff, A. B.: Distribution of peroxisomes (microbodies) in the nephron of the rat. A cytochemical study. J. cell Biol. 42, 501–518 (1969)
Black, V. H., Bogart, B. J.: Peroxisomes in inner adrenocortical cells of fetal and adult guinea pigs. J. Cell Biol. 57, 345–358 (1973)
Duve, C. de: Biochemical studies on the occurence, biogenesis and life history of mammalian peroxisomes. J. Histochem. Cytochem. 21, 941–948 (1973)
Dvořák, A., Konečná, H., Štastná, J.: Differentiation of microbodies of hepatic cell during ontogenesis. Arch. Anat. Gist. Embriol. 52, 86–93 (1967a)
Dvořák, A., Konečná, H., Štastná, J.: Differentiation of microbodies and lysosomes of the liver cell during ontogenesis. Scr. med. Fac. Med. Brun. 40, 49–50 (1967b)
Hruban, Z., Vigil, E. L., Slesers, A., Hopkins, E.: Microbodies, constituent organelles of animal cells. Lab. Invest. 72, 184–191 (1972)
Lazarow, P. B., Duve, C. de: The synthesis and turnover of rat liver peroxisomes. V. Intracellular pathway of catalase synthesis. J. Cell Biol. 59, 507–524 (1973)
Novikoff, A. B., Novikoff, P. M., Davis, C., Quintana, R.: Studies on microperoxisomes II. A cytochemical method for light and electron microscopy. J. Histochem. Cytochem. 20, 1006–1023 (1972)
Novikoff, A. B., Novikoff, P. M., Davis, C., Quintana, N.: Studies on microperoxisomes V. Are microperoxisomes ubiquitous in mammalian cells? J. Histochem. Cytochem. 21, 737–755 (1973b)
Novikoff, P. M., Novikoff, A. B.: Peroxisomes in absorptive cells of mammalian small intestine. J. Cell Biol. 53, 532–560 (1972)
Novikoff, P. M., Novikoff, A. B., Quintana, N., Davis, C.: Studies on microperoxisomes III. Observations on human and rat hepatocytes. J. Histochem. Cytochem. 21, 540–558 (1973a)
Reynolds, E. S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208 (1963)
Tsukada, H., Mochizuki, Y., Konishi, T.: Morphogenesis and development of microbodies of hepatocytes on rats during pre- and postnatal growth. J. Cell Biol. 37, 231–243 (1968)
Wood, R. L.: Electron microscope localization of phosphatase activity in developing rat liver. J. Cell Biol. 35, 146A (1967)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pipan, N., Pšeničnik, M. The development of microperoxisomes in the cells of the proximal tubules of the kidney and epithelium of the small intestine during the embryonic development and postnatal period. Histochemistry 44, 13–21 (1975). https://doi.org/10.1007/BF00490416
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00490416