Summary
The distribution pattern of histochemically detectable 5′-nucleotidase (5′-Nase) activity is described in stratified squamous epithelia (epidermis, cornea, tongue, mucous membrane of the oral cavity, esophagus and vagina) and skin appendages (hair, sebaceous glands and sweat glands). The data were gained by having studied mice, rats and guinea pigs. Particular attention is paid to species differences as well as to different enzyme activities which can be demonstrated in stratified squamous epithelia of various organs in the same species.
Several examples are given for a positively reacting stratum basale or stratum germinativum (e.g. epidermis and vaginal epithelium of rats, esophageal and vaginal epithelium of guinea pigs, sebaceous glands of rats). It turns out that histochemically demonstrable amounts of 5′-Nase activity are not restricted to nonproliferating normal tissues. This finding indicates that the function of 5′-Nase cannot be limited to a degradative role in nucleoside phosphates metabolism as hypothesized in the literature.
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This paper is dedicated to Professor Dr. O. Hoffmann-Ostenhof on the occasion of his 60th birthday.
Supported by a grant of “Hochschuljubiläumsstiftung der Stadt Wien”.
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Klaushofer, K., Böck, P. Studies on 5′-nucleotidase histochemistry. Histochemistry 40, 39–49 (1974). https://doi.org/10.1007/BF00490272
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DOI: https://doi.org/10.1007/BF00490272