, Volume 40, Issue 1, pp 31–37 | Cite as

Intracellular aluminum binding; A histochemical study

  • U. De Boni
  • J. W. Scott
  • D. R. Crapper


Although aluminum is neurotoxic, the mechanisms and sites of action are unknown. Using the histochemical stains, morin and Solochrome Azurine, intracellular binding of aluminum was examined in brain tissues of animals with an aluminum induced encephalopathy, in human lymphocytes and in cells of plant meristems. Accumulation of aluminum occurred on chromatin of interphase nuclei and on chromosomes of mitotic cells. These findings suggest that neurofibrillary degeneration following the intracerebral injection of aluminum salts in experimental animals may be the results of interactions between aluminum and chromatin.


Public Health Aluminum Experimental Animal Brain Tissue Morin 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • U. De Boni
    • 1
    • 2
  • J. W. Scott
    • 1
    • 2
  • D. R. Crapper
    • 1
    • 2
  1. 1.Department of PhysiologyUniversity of TorontoTorontoCanada
  2. 2.Department of MedicineUniversity of TorontoTorontoCanada

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