, Volume 38, Issue 1, pp 27–33 | Cite as

On the nature of the amyloid in human islets of langerhans

  • Per Westermark


The occurrence of tryptophane and tyrosine in islet amyloid and some other amyloids was investigated by histochemical methods. Tryptophane was found to be present in all amyloids studied except islet amyloid. The presence of tyrosine was shown in all amyloids but the staining for this amino acid was rather weak in islet amyloid. Fibrillar insulin also exhibited only weak staining for tyrosine. This insulin was strongly stained by Congo red and showed clear green birefringence when studied in polarized light. These results and the finding that insulin antibodies become bound to islet amyloid after treatment for reactivation of fibrillar insulin may indicate that fibrillar insulin or at least a part of the insulin molecule might be an important constituent of islet amyloid.


Public Health Tyrosine Tryptophane Human Islet Weak Staining 
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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Per Westermark
    • 1
    • 2
  1. 1.Department of PathologyUniversity of UppsalaUppsalaSweden
  2. 2.Institute of PathologyUppsalaSweden

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