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European Journal of Pediatrics

, Volume 125, Issue 2, pp 97–102 | Cite as

Hepatic enzymes, their induction and usefulness in predicting maximal serum bilirubin levels in premature newborn infants

  • H. Bartels
  • A. Fenner
  • W. van der Merwe
  • S. Barbalatt
  • J. Wolfsdorf
Article

Abstract

Sixty-seven babies were utilized to (a) document the serum bilirubin lowering effect and safety of a phenobarbitone and nikethamide combination in neonatal hyperbilirubinaemia of non-hemolytic origin; (b) determine whether birthweight and/or SGOT, SGPT or SGGT activity on day one of life correlated with the maximum serum bilirubin level achieved; and (c) investigate the pattern of hepatic enzyme levels in serum under normal conditions and following drug induction. Results indicate a significantly lower serum bilirubin level in the treated group of babies. Birthweight and day one SGGT levels, and SGGT/birthweight ratio correlated well with the maximum serum bilirubin reached, the latter ratio being particularly useful in predicting the degree of hyperbilirubinaemia.

Key words

Gamma-glutamyl transferase Enzyme induction Neonatal jaundice Combined phenobarbitone-nikethamide prophylaxis 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • H. Bartels
    • 1
  • A. Fenner
    • 2
  • W. van der Merwe
    • 3
  • S. Barbalatt
    • 3
  • J. Wolfsdorf
    • 3
  1. 1.Department of PediatricsUniversity of KielKielFederal Republic of Germany
  2. 2.Division of NeonatologyMedical SchoolLübeckFederal Republic of Germany
  3. 3.Department of Pediatrics and Child Health, Godfrey Huggins School of MedicineUniversity of RhodesiaSalisburyRhodesia

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