Summary
The “Sex Reversed” factor (Sxr) leads to development of XX males. The condition is transmitted by XY-Sxr males. The testes of XY-Sxr carriers are characterized by patches of defective spermatogenesis with meiotic failure and appearance of extraordinary large spermatids. In the present study DNA content of the large spermatids is determined by Feulgen DNA measurement using a scanning cytophotometer. The large spermatids in XY-Sxr testes are shown to be 2n.
Similar content being viewed by others
References
Cattanach BM (1975) Sex reversal in the mouse and other mammals. In: Balls M, Wild A (eds) The early development of mammals. Cambridge University Press, Cambridge, pp 305–317
Cattanach BM, Pollard CE, Hawkes SG (1971) Sex-reversed mice: XX and X0 males. Cytogenetics 10:318–337
DeLaChapelle A (1972) Analytic review: nature and origin of males with XX sex chromosomes. Am J Hum Genet 24:71–105
Fukuda M, Böhm N, Fujida S (1978) Cytophotometry and its biological application. Prog Histochem Cytochem 11:1
Hannappel E, Drews U (1979) Mosaic character of spermatogenesis in carriers of the sex reversed factor in the mouse. Horm Metab Res 11:682–689
Hansmann J, El-Nahass E (1979) Incidence of nondisjunction in mouse oocytes. Cytogenet Cell Genet 24:115–121
Lyon MF (1972) X-chromosome inactivation and developmental patterns in mammals. Biol Rev 47:1–35
Masui Y, Meyerhof PG, Miller MA, Wasserman WJ (1977) Roles of divalent cations in maturation and activation of vertebrate oocytes. Differentiation 9:49–57
Author information
Authors and Affiliations
Additional information
This study is dedicated to Prof. Dr. W. Graumann on occasion of his 65th birthday
Rights and permissions
About this article
Cite this article
Hannappel, E., Siegler, W. & Drews, U. Demonstration of 2n spermatids in carriers of the “sex reversed” factor in the mouse by feulgen cytophotometry. Histochemistry 69, 299–306 (1980). https://doi.org/10.1007/BF00489775
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00489775