Summary
The binding and uptake of lead by the jejunal, colonic and gallbladder epithelium of guinea pig has been investigated by electron microscopy. Binding occurred rapidly, the most marked by the microvilli was by the jejunum, followed by colon and gallbladder. The tracer was subsequently internalised in small membrane bound vesicles and smooth endoplasmic reticulum. By 30 min, it appeared in multivesicular bodies at all three sites.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barbour WMcA, Hopwood D (1983) Uptake of cationized ferritin by colonic epithelium. J Pathol 139:167–178
Blok J, Mulder-Stapel AA, Ginsel LA, Daems WT (1980) Binding of cationized ferritin to the cell coat glycoprotein of human and rat small intestinal absorptive cells. Histochemistry 69:131–135
Coghill SB, Hopwood D, McPherson S, Hislop S (1983) The ultrastructural localization of De-Nol in the upper gastrointestinal tract of man and rodents following oral and instrumental administration. J Pathol 139:105–114
Coleman JR, Young LB (1979) Metal binding by intestinal mucus. Scanning Electron Microsc 2:801–806
Conrad ME, Barton JC (1978) Factors affecting the adsorption and excretion of lead in the rat. Gastroenterology 74:731–740
Cullen MR, Robins JM, Eskanzi B (1983) Adult inorganic lead intoxidation: Presentation of 31 new cases and a review of recent advances in the literature. Medicine 62:221–247
Flanagan PR, Hamilton DL, Haist J, Valberg LS (1979) Interrelationships between iron and lead absorption in iron deficient mice. Gastroenterology 77:1074–1081
Gerber GB, Léonard A, Jacquet P (1950) Toxicity, mutagenicity and teratogenicity of lead. Mutat Res 76:115–141
Gruden N, Stantic M (1975) Transfer of lead through the rat's intestinal wall. Sci Total Environment 3:288–292
Holtzman RB (1978) Application of radio lead to metabolic studies in: the giogeochemistry of lead in the environment ed JO Nriagu. Elsevier, North Holland Oxford, pp 37–96
Hopwood D, Milne F, Wood RAB (1982) The uptake of cationized ferritin and its subsequent redistribution by gallbladder epithelium in vivo. J Pathol 136:95–109
Hursh JB, Suomela J (1968) Absorption 212Pb from the gastrointestinal tract of man. Acta Radiol 7:108–120
Kehoe RA, Thamann F, Cholak J (1933) On the normal absorption and excretion of lead. I. Lead absorption and excretion in primitive life. J Ind Hyg 15:257–272
Pfleger K (1975) Methods for the investigation of absorption in animals. In: International Encyclopedia of Pharmacology and therapeutics, sect 39B, Vol II. pp 797–817
Phillips SF, Devroede GS (1979) Functions of the large intestine. Int Rev Physiol 19:263–290
Simson JAN, Dom RM (1983) The use of lead as an ionic tracer for investigating routes of passive fluid transfer. J Histochem Cytochem 31:675–683
Watson WS, Hume R, Moore MR (1980) Oral absorption of lead and iron. Lancet 2:236–237
Wrong OM, Edmonds CJ, Chadwick VS (1981) The large intestine: its role in mammalian nutrition and homeostasis. MTP Press, Lancaster
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hussein, K.A., Coghill, S.B., Milne, G. et al. The uptake of lead by small intestine, colon and gallbladder of the guinea pig in vivo. Histochemistry 81, 591–596 (1984). https://doi.org/10.1007/BF00489540
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00489540