Biochemical Genetics

, Volume 21, Issue 11–12, pp 1153–1166 | Cite as

Comparative properties of three forms of glucose-6-phosphate dehydrogenase in Drosophila melanogaster

  • John H. Williamson
  • Michael M. Bentley


Three alleles of the Zw locus of Drosophila melanogaster—ZwA, ZwB,and Zwlol—apparently code for dimeric, tetrameric, and monomeric forms of glucose-6-phosphate dehydrogenase (G6PD), respectively. The three forms of G6PD are characterized by different apparent Kmvalues for glucose-6-phosphate but similar apparent Kmvalues for NAPD+. When high concentrations of NAPD+ were added to enzyme preparations, the ZwAand Zwlolforms of G6PD assumed tetrameric and dimeric properties, respectively. Although Zwloladults exhibit little G6PD activity, they maintain levels of G6PD-antigen comparable to those in ZwAand ZwBadults. Thus the low level of G6PD activity in Zwlolindividuals cannot be explained as the consequence of lack of synthesis of the G6PD subunit.

Key words

Drosophila melanogaster glucose-6-phosphate dehydrogenase 


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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • John H. Williamson
    • 1
  • Michael M. Bentley
    • 2
  1. 1.Department of BiologyDavidson CollegeDavidson
  2. 2.Department of BiologyUniversity of CalgaryCalgaryCanada

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