Biochemical Genetics

, Volume 9, Issue 2, pp 117–130 | Cite as

Genetic control of two esterases of rat plasma (Rattus norvegicus)

  • O. L. Serov


Three electrophoretic variants of plasma esterase in the albumin zone, presumably carboxylesterase, have been demonstrated in 250 rats representing a laboratory population of Wistar rats. Electrophoretic variants of the enzyme are believed to be controlled by two codominant alleles at the autosomal locus referred to as Es-2. The variant of carboxylesterase represented by a fast-migrating single band on starch gel electrophoresis is determined by the gene named Es-2a, whereas the slow-migrating variant, represented by two bands, is under control of the allelic gene Es-2b. Animals with Es-2a/Es-2b genotype have three bands of carboxylesterase in the albumin zone. Genetically determined polymorphism of plasma esterase, presumably carboxylesterase, in the prealbumin zone was shown in both laboratory and wild populations of rats. Breeding tests suggest that the gene referred to as Es-1a, responsible for the presence of carboxylesterase in the prealbumin zone, is inherited dominantly, whereas animals homozygous for the allele Es-1b locked this esterase fraction.


Starch Albumin Wild Population Genetic Control Single Band 


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Copyright information

© Plenum Publishing Corporation 1973

Authors and Affiliations

  • O. L. Serov
    • 1
  1. 1.Institute of Cytology and GeneticsSiberian Branch of the Academy of Sciences of U.S.S.R.NovosibirskUSSR

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