Abstract
The patterns governing the dependence of NH-acidity on the presence of α-, Β- and γ-substituents in the 1,4-dihydropyridine ring and on their nature have been established by comparison of the pKa values of monocyclic 1,4-dihydropyridines and 4,5-dihydroindenopyridines. Additional data were obtained on the influence of the the electronic effects of sulfur-containing substitutents on the reaction center in the dihydropyridine molecules.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1228–1231, September, 1989.
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Vigante, B.A., Terekhova, M.I., Ozols, Y.Y. et al. Equilibrium NH-acidity of 1,4-dihydropyridines and 4,5-dihydroindeno[1,2-b]pyridines. Chem Heterocycl Compd 25, 1028–1031 (1989). https://doi.org/10.1007/BF00487303
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DOI: https://doi.org/10.1007/BF00487303