Abstract
The quinuclidine ring in the reaction of 2-ethoxycarbonyl-3-oxoquinuclidine with nucleophilic reagents under mild conditions is cleaved at the C2-C3 bond to give 1-carboxymethylisonipecotic acid and its derivatives.
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Yu. N. Sheinker, E. M. Peresleni, I. V. Persianova, E. E. Mikhlina, V. Ya. Vorob'eva, A. D. Yanina, and L. N. Yakhontov, Khim. Geterotsikl. Soedin., 229 (1972).
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1125–1128, August, 1974.
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Mikhlina, E.E., Vorob'eva, V.Y., Londoreva, G.P. et al. Reaction of 2-ethoxycarbonyl-3-oxoquinuclidine with nucleophilic reagents. Chem Heterocycl Compd 10, 977–980 (1974). https://doi.org/10.1007/BF00487124
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DOI: https://doi.org/10.1007/BF00487124