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Biochemical Genetics

, Volume 11, Issue 1, pp 41–47 | Cite as

X linkage of phosphoglycerate kinase in the mouse

  • Leslie P. Kozak
  • Gordon K. McLean
  • Eva M. Eicher
Article

Abstract

The levels of phosphoglycerate kinase (PGK), glucose 6-phosphate dehydrogenase (G6PD), and lactate dehydrogenase (LDH) were measured in one-cell embryos from X/0 and X/X females. Since the level of both PGK and G6PD was dependent on the number of X chromosomes present in the mother, these two enzymes are most likely coded for by X-linked genes. The level of LDH was the same in both types of embryos, indicating autosomal linkage. A search for an electrophoretic variant of PGK was not successful.

Key words

phosphoglycerate kinase (PGK) X chromosome X/0 mouse embryos glucose 6-phosphate dehydrogenase (G6PD) lactate dehydrogenase (LDH) 

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Copyright information

© Plenum Publishing Corporation 1974

Authors and Affiliations

  • Leslie P. Kozak
    • 1
  • Gordon K. McLean
    • 2
  • Eva M. Eicher
    • 1
  1. 1.The Jackson LaboratoryBar Harbor
  2. 2.Dartmouth Medical SchoolHanover

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