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Adh n5: A temperature-sensitive mutant at the Adh locus in Drosophila

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Abstract

Individuals of an alcohol dehydrogenase-negative strain of Drosophila melanogaster designated Adh n5 are resistant to ethanol poisoning at low but not at high temperatures. The basis for this behavior is that Adh n5 flies contain a mutant form of alcohol dehydrogenase which is less heat stable than that of wild-type flies. The mutation in Adh n5 maps at, or very close to, the presumptive structural locus and is not complemented by any of 11 other alcohol dehydrogenase-null mutants.

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Authors and Affiliations

  1. Department of Biology, Johns Hopkins University, Baltimore, Maryland

    Charles Vigue & William Sofer

Authors
  1. Charles Vigue
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  2. William Sofer
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Additional information

This research was supported by Grant No. GM 18254 from the National Institutes of Health and Grant No. M55.2217 from the National Cancer Institute.

Publication No. 768 from the Department of Biology, Johns Hopkins University.

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Vigue, C., Sofer, W. Adh n5: A temperature-sensitive mutant at the Adh locus in Drosophila . Biochem Genet 11, 387–396 (1974). https://doi.org/10.1007/BF00486412

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  • DOI: https://doi.org/10.1007/BF00486412

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