Biochemical Genetics

, Volume 6, Issue 2–3, pp 125–138 | Cite as

Esterase polymorphisms in Microtus ochrogaster: interaction and linkage

  • Robert Semeonoff


Three polymorphic loci have been identified in the prairie vole, Microtus ochrogaster. Together they control a group of plasma esterases which can be separated using starch gel electrophoresis. A structural locus, Es-1, produces an enzyme which from genetic evidence appears to be a dimer. The allele Es-1a produces a wholly active subunit, and homozygotes give a single enzyme band. The product of the second allele, Es-1o, cannot form active enzyme on its own but will dimerize with the Es-1a subunit, giving a hybrid enzyme with a slower electrophoretic mobility than the pure Es-1a enzyme. The third allele, Es-1, has no detectable product. A second structural locus, Es-2, is linked to Es-1. The allele Es-2a produces a single enzyme band, but the second allele Es-2 has no detectable product. A modifier locus, Me, changes the mobility of the Es-1 enzymes. Mef is dominant over mes, and in homozygotes for mes the mobility is reduced.


Active Enzyme Starch Electrophoretic Mobility Structural Locus Polymorphic Locus 
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Copyright information

© Plenum Publishing Corporation 1972

Authors and Affiliations

  • Robert Semeonoff
    • 1
  1. 1.Department of ZoologyIndiana UniversityBloomington

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