Abstract
A study of the erythrocyte carbonic anhydrases of 330 Japanese horses revealed the presence of six major enzymes. All horses possessed a single C-type enzyme. Thoroughbred racing horses had only the B-type carbonic anhydrase designated as D, but some farm horses also had others with electrophoretic mobilities corresponding to the human B, A, and T enzymes. A study of the distribution of these B-type allelic products indicated that their synthesis is controlled by a pair of codominant autosomal alleles as previously reported for the horse and other species.
Similar content being viewed by others
References
Funakoshi, S., and Deutsch, H. F. (1969). Human carbonic anhydrases. II. Some physico-chemical properties of native isozymes and of similar isozymes generated in vivo. J. Biol. Chem. 2443438.
Funakoshi, S., and Deutsch, H. F. (1970). Human carbonic anhydrases. IV. Properties of a mutant B type isozyme. J. Biol. Chem. 2454913.
Funakoshi, S., and Deutsch, H. F. (1971a). Human carbonic anhydrases. VI. Levels of isozymes in old and young erythrocytes and in various tissues. J. Biol. Chem. 2461088.
Funakoshi, S., and Deutsch, H. F. (1971b). Animal carbonic anhydrase isozymes. Comp. Biochem. Physiol. 39B489.
Furth, A. J. (1968). Purification and properties of horse erythrocyte carbonic anhydrases. J. Biol. Chem. 2434832.
Moore, M. J., Funakoshi, S., and Deutsch, H. F. (1971). Human carbonic anhydrases. VIII. A new C type isozyme in erythrocytes of American Negroes. Biochem. Genet. 5497.
Nyman, P. U. (1961) Purification and properties of carbonic anhydrase from human erythrocytes. Biochim. Biophys. Acta 521.
Rickli, E. E., Ghazanfar, S. A. S., Gibbons, B. H., and Edsall, J. T. (1964). Carbonic anhydrases from human erythrocytes. Preparation and properties of two enzymes. J. Biol. Chem. 2391065.
Sandberg, K. (1968). Genetic polymorphism in carbonic anhydrase from horse erythrocytes. Hereditas 60411.
Sandberg, K. (1970). Blood group factors and erythrocytic protein polymorphism in Swedish horses. In XI European Conference on Animal Blood Groups and Biochemical Polymorphism, Dr. W. Junk N. V., Pub., The Hague, Netherlands, p. 447.
Satore, G., Stormont, C., Morris, B. G., and Grunder, A. A. (1969). Electrophoretic forms of esterase and carbonic anhydrase in red cells of cattle and bison. Genetics 61823.
Shows, T. B. (1967). The amino acid substitution and some chemical properties of a variant human erythrocyte carbonic anhydrase Id Michigan. Biochem. Genet. 1171.
Smithies, O. (1965). Disulfide-bond cleavage and formation in proteins. Science 1501595.
Tashian, R. E. (1969). In Yunis, J. (ed.), Biochemical Methods in Red Cell Genetics, Academic Press, New York, p. 307.
Tashian, R. E., Riggs, S. K., and Yu, Y.-S. L. (1966). Characterization of a mutant human erythrocyte carbonic anhydrase: Carbon anhydrase IcGuam. Arch. Biochem. Biophys. 117320.
Tashian, R. E., Goodman, M., Headings, V. E., DeSimone, J., and Ward, R. H. (1971). Genetic variation and evolution in the red cell carbonic anhydrase isozymes of macaque monkeys. Biochem. Genet. 5183.
Tsuchihashi, M. (1923). Zur Kenntnis der Blutkatalase. Biochem. Z. 14063.
Tucker, E. M., Suzuki, Y., and Stormont, C. (1967). Three new phenotypic systems in the blood of sheep. Vox Sang 13246.
Wilbur, K. M., and Anderson, N. G. (1948). Electrometric and colorimetric determination of carbonic anhydrase. J. Biol. Chem. 176147.
Author information
Authors and Affiliations
Additional information
This work was supported in part by Grant No. C-1786 from the U.S. Public Health Service and by the Japan Society for the Promotion of Science.
Visiting professor.
Rights and permissions
About this article
Cite this article
Deutsch, H.F., Taniguchi, N., Funakoshi, S. et al. Distribution of erythrocyte carbonic anhydrase B-type alleles in Japanese farm horses. Biochem Genet 6, 255–262 (1972). https://doi.org/10.1007/BF00486119
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00486119