Biochemical Genetics

, Volume 9, Issue 4, pp 343–349 | Cite as

Enzymes of the glucuronic acid pathway in Wistar and Gunn rats and their heterozygotes

  • Raija Puukka
  • Pirjo Tanner
  • Osmo Hänninen


A significant difference in UDP glucuronyltransferase activity (with p-nitrophenol as an acceptor) was found in the liver and kidneys of homozygous Wistar and Gunn rats. There was also a significant difference in hepatic UDP glucuronyltransferase activity between homozygous Wistar and heterozygous Gunn rats when the enzyme preparations were first activated by adding surfactants to the reaction mixture. This determination of surfactant-activated UDP glucuronyltransferase can be used to distinguish Wistar rats from heterozygous Gunn rats. Other enzymes of the glucuronic acid pathway were also studied in the liver and kidneys of homozygous Wistar and Gunn rats, but no differences were found.


Enzyme Preparation Glucuronic Acid Acid Pathway Glucuronyltransferase Activity Glucuronic Acid Pathway 
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Copyright information

© Plenum Publishing Corporation 1973

Authors and Affiliations

  • Raija Puukka
    • 1
  • Pirjo Tanner
    • 1
  • Osmo Hänninen
    • 1
  1. 1.Department of Biochemistry and Department of PhysiologyUniversity of TurkuFinland

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