Abstract
Two alleles at each of four esterase loci in Rattus norvegicus are described with regard to tissue expression, electrophoretic characterization, and genetic linkage. A previously described dominant gene for prealbumin serum esterase is demonstrated to exist as two codominant alleles in the genetically determined absence of the characteristic albumin esterase. The allelic composition of 16 inbred strains for four esterase genes is provided, and the heretofore ambiguous nomenclature of rat esterase genetics is standardized. Linkage of Es-1, Es-2, and Es-3 is demonstrated. Es-2 and Es-3 are tightly linked in that no recombination has been observed in 55 offspring. The same offspring demonstrated 9% recombination between Es-1 and the other two loci.
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References
Augustinsson, K. B., and Henricson, B. (1966). A genetically controlled esterase in rat plasma. Biochim. Biophys. Acta 123323.
Boyer, S. H., Fainer, D. C., and Naughton, M. A. (1963). Myoglobin: Inherited structural variation in man. Science 1401228.
Grunder, A. A., Sartore, G., and Stormont, C. (1965). Genetic variation in red cell esterases of rabbits. Genetics 521345.
Hunter, R. L., and Markert, C. L. (1957). Histochemical demonstration of enzymes separated by zone electrophoresis in starch-gels. Science 1251294.
IUPAC-IUB Commission on Biochemical Nomenclature (1971). The Nomenclature of multiple forms of enzymes—Recommendations. Arch. Biochem. Biophys. 1471.
Kristjansson, F. K. (1960). Genetic control of two blood serum proteins in swine. Can. J. Genet. Cytol. 2295.
Petras, M. L., and Sinclair, P. (1969). Another esterase variant in the kidney of the house mouse, Mus musculus. Can. J. Genet. Cytol. 1197.
Popp, R. A. (1966). Inheritance of an erythrocyte and kidney esterase in the mouse. J. Hered. 57197.
Popp, R. A., and Popp, D. M. (1962). Inheritance of serum esterases having different electrophoretic patterns among inbred strains of mice. J. Hered. 53111.
Ruddle, R. H., and Roderick, T. H. (1966). The genetic control of two types of esterases in inbred strains of the mouse. Genetics 54191.
Ruddle, R. H., Shows, T. B., and Roderick, T. H. (1968). Esterase genetics in Mus musculus: Expression, linkage, and polymorphism of locus Es-2. Genetics 62393.
Schiff, R., and Stormont, C. (1970). The biochemical genetics of rabbit erythrocyte esterases: Two esterase loci. Biochem. Genet. 411.
Stormont, C., and Suzuki, Y. (1970). Atropinesterase and cocainesterase of rabbit serum: Localization of the enzyme activity in isozymes. Science 167200.
Womack, J. E. (1972a). Genetic control of the major electrophoretic component of rat plasma esterase. J. Hered. 6341.
Womack, J. E. (1972b). Genetic control of an esterase of digestive tract tissues in Rattus norvegicus. Experientia 281372.
Yamori, Y., and Okamoto, K. (1970). Zymogram analysis of various organs from spontaneously hypertensive rats: A geneticobiochemical study. Lab. Invest. 22206.
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This work was supported by a grant from the Brown-Hazen Fund of Research Corporation.
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Womack, J.E. Biochemical genetics of rat esterases: Polymorphism, tissue expression, and linkage of four loci. Biochem Genet 9, 13–24 (1973). https://doi.org/10.1007/BF00485587
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DOI: https://doi.org/10.1007/BF00485587