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Genetic variation in the carbonic anhydrase isozymes of macaque monkeys. II. Inheritance of red cell carbonic anhydrase levels in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestrina

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Abstract

The inheritance of red blood cell levels of carbonic anhydrase isozymes (CA I and CA II) has been studied in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestrina. Quantitation of CA I isozymes in a series of animals indicates that the total CA I concentration is the sum of the average effects of each CA I structural allele and that the average effects are independent of the various allelic combinations. The relative average effects were 0.32:0.95:1.0 for the CA I a, CA Ib, and CA I c structural genes, respectively. It is also demonstrated that the level of CA II is related to the CA I genotypes. Multiple regression analysis demonstrated that each dose of CA I-deficiency gene present decreased the CA II concentration by approximately 30%, with this decrease in CA II level being solely related to the dose of CA I-deficiency gene and not to the level of CA I. The CA I-deficient animals produce CA I products that are similar to the common CA Ia, CA Ib, CA Ic electrophoretic types. Limited mating data indicate that the CA I components in CA I-deficient animals are inherited codominantly.

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Author notes

  1. Erik Magid (U.S. Public Health Service International Postdoctoral Fellow)

    Present address: Department of Clinical Chemistry, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen NV, Denmark

Authors and Affiliations

  1. Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan

    Joseph DeSimone, Erik Magid (U.S. Public Health Service International Postdoctoral Fellow) & Richard E. Tashian

Authors
  1. Joseph DeSimone
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  2. Erik Magid
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  3. Richard E. Tashian
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Additional information

Supported by U.S. Public Health Service Research Grant GM-15419.

This report is a portion of a dissertation submitted to the University of Michigan in partial fulfillment of the requirements for the Doctor of Philosophy degree.

U.S. Public Health Service Predoctoral Trainee (GM-71-14).

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DeSimone, J., Magid, E. & Tashian, R.E. Genetic variation in the carbonic anhydrase isozymes of macaque monkeys. II. Inheritance of red cell carbonic anhydrase levels in different carbonic anhydrase I genotypes of the pig-tailed macaque, Macaca nemestrina . Biochem Genet 8, 165–174 (1973). https://doi.org/10.1007/BF00485544

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  • DOI: https://doi.org/10.1007/BF00485544

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