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Biochemical Genetics

, Volume 1, Issue 3, pp 229–237 | Cite as

Glucose 6-phosphate dehydrogenase in Drosophila: A sex-influenced electrophoretic variant

  • Donald J. Komma
Article

Abstract

A variant of glucose 6-phosphate dehydrogenase (G6PD) in Drosophila melanogaster shows different electrophoretic migration in males and females. In heterozygotes, the variant influences the migration of G6PD produced by both chromosomes. Mixing of homogenates of males and females changes migration of the female-produced enzyme, suggesting that a protein produced in males is capable of altering the variant G6PD molecule. The hypothetical protein is also present in pseudomales and intersexes produced by sex transformation genes.

Keywords

Glucose Hypothetical Protein Transformation Gene Electrophoretic Migration Electrophoretic Variant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bridges, C. B., and Brehme, K. S. (1944). The mutants of Drosophila melanogaster. Carnegie Inst. Wash. Publ. 552.Google Scholar
  2. Chen, P. S., and Diem, C. (1961). A sex-specific ninhydrin-positive substance found in the paragonia of adult males of Drosophila melanogaster. J. Insect. Physiol. 7 289.Google Scholar
  3. Fox, A. S., Mead, G. G., and Munyon, I. L. (1959). Sex peptide of Drosophila melanogaster. Science 129 1489.Google Scholar
  4. Griffin, M. J., and Cox, R. P. (1966). Studies on the mechanisms of hormone induction of alkaline phosphatase in human cell cultures. II. Rate of enzyme synthesis and properties of base level and induced enzymes. Proc. Natl. Acad. Sci. (U.S.) 56 946.Google Scholar
  5. Hildreth, P. E. (1965). Doublesex, a recessive gene that transforms both males and females of Drosophila into intersexes. Genetics 51 659.Google Scholar
  6. Komma, D. J. (1966a). Differential assay of G-6-PD produced by individual X chromosomes in heterozygous D.m. females. Drosophila Information Service 41 189.Google Scholar
  7. Komma, D. J. (1966b). Effect of sex transformation genes on glucose-6-phosphate dehydrogenase activity in Drosophila melanogaster. Genetics 54 497.Google Scholar
  8. Morgan, Th., Redfield, H., and Morgan, L. V. (1943). Maintenance of a Drosophila stock center in connection with investigations on the constitution of germinal material in relation to heredity. Carnegie Inst. Wash. Yearbook 42 171.Google Scholar
  9. Muller, H. J. (1950). Evidence of the precision of genetic adaptation. Harvey Lectures Ser. XLIII, 165.Google Scholar
  10. Murray, R. F., and Ball, J. A. (1967). Testis-specific and sex-associated hexokinases in Drosophila melanogaster. Science 156 81.Google Scholar
  11. Sturtevant, A. H. (1945). A gene in Drosophila melanogaster that transforms females into males. Genetics 30: 297.Google Scholar
  12. Young, W. J. (1966). X-linked electrophoretic variation in 6-phosphogluconate dehydrogenase in Drosophila melanogaster. J. Hered. 57 58.Google Scholar
  13. Young, W. J., Porter, J. E., and Childs, B. (1964). Glucose-6-phosphate dehydrogenase in Drosophila: X-linked electrophoretic variants. Science 143 140.Google Scholar

Copyright information

© Plenum Publishing Corporation 1968

Authors and Affiliations

  • Donald J. Komma
    • 1
  1. 1.Department of Biological SciencesColumbia UniversityNew York

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