Abstract
Two sublines of commercially available Long-Evans hooded rats have been developed by genetic selection. These sublines have widely differing levels of erythrocyte 2,3-diphosphoglycerate (DPG) due to different alleles at a single genetic locus. In the present work, it is shown that rats from the commercial population are also polymorphic at a hemoglobin locus, probably involving two alleles of the IIIβ-globin chain locus. Particular hemoglobin types have been found to be strongly associated with certain DPG types, not only in the high-DPG and low-DPG lines but also in the commercial population. Two explanations for this association are considered. One is a single-locus hypothesis, with hemoglobin allelic variation causing DPG variation, and the other is a two-locus hypothesis, with marked linkage disequilibrium.
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This work was supported by a Michigan Heart Association Grant, by the Meyers Foundation, and by NIH Training Grant (5 T01-GM-0071).
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Brewer, G., Gilman, J., Noble, N. et al. Association in Long-Evans hooded rats of red cell 2,3-diphosphoglycerate levels with hemoglobin types. Biochem Genet 16, 695–707 (1978). https://doi.org/10.1007/BF00484727
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DOI: https://doi.org/10.1007/BF00484727