Biochemical Genetics

, Volume 18, Issue 7–8, pp 793–808 | Cite as

Studies of primate protein variation and evolution: Microelectrophoretic detection

  • Roberta M. Palmour
  • John E. Cronin
  • Anne Childs
  • Benjamin W. Grunbaum


Genetic variation at 16 protein and enzyme loci in Cercopithecus aethiops and several other primate species has been surveyed, using cellulose acetate microelectrophoresis. Resolution of several standard variant proteins is comparable to that achieved on starch gel or polyacrylamide gel. Although both intraspecific and interspecific variation was observed for some loci, the data generally support the concept that extracellular proteins are more likely to be polymorphic within a species, while intracellular proteins generally vary between species, if at all. These methodologies are particularly appropriate for screening multiple-locus variation in large numbers of samples; their relevance to studies of molecular evolution and evaluation of theories of kin selection is discussed.

Key words

enzyme and protein variation primate genetic variation and evolution electrophoresis 


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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • Roberta M. Palmour
    • 1
  • John E. Cronin
    • 2
  • Anne Childs
    • 1
  • Benjamin W. Grunbaum
    • 3
  1. 1.Department of GeneticsUniversity of CaliforniaBerkeley
  2. 2.Neuropsychiatric InstituteUniversity of CaliforniaLos Angeles
  3. 3.White Mountain Research LaboratoriesUniversity of CaliforniaUSA

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