Biochemical Genetics

, Volume 18, Issue 7–8, pp 781–791 | Cite as

Developmental regulation of phenylalanine hydroxylase activity in Drosophila melanogaster

  • John E. Geltosky
  • Herschel K. Mitchell


Herein we demonstrate that Drosophila larvae possess a synthetic activity capable of converting phenylalanine to tyrosine. This system is readily extractable and displays many characteristics of phenylalanine hydroxylase systems described in other organisms, the most notable being that a tetrahydropteridine is required for full expression of activity. The level of phenylalanine hydroxylase activity present in the organism varies with the stage of development: from an undetected level of activity at the first larval instar, there is a rapid increase in phenylalanine hydroxylase activity which reaches a peak at the time of puparium formation, after which there is a rapid decrease again to an undetected level.

Key words

Drosophila phenylalanine hydroxylase developmental regulation 


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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • John E. Geltosky
    • 1
  • Herschel K. Mitchell
    • 2
  1. 1.Photo Products DivisionE. I. Dupont Co.Wilmington
  2. 2.Division of BiologyCalifornia Institute of TechnologyPasadena

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