Biochemical Genetics

, Volume 15, Issue 1–2, pp 123–135 | Cite as

Relationship between enzyme heterozygosity and quaternary structure

  • Robert D. Ward


The need for proteins to maintain particular quaternary structures constrains variability in amino acid sequence. Monomeric enzymes are then expected to be more variable than dimeric forms, which in turn are expected to be more variable than tetrameric forms. These predictions are confirmed by analysis of available data on enzyme variation. Theories relating enzyme heterozygosity to metabolic function are discussed in the light of these findings.

Key words

enzyme polymorphism enzyme structure enzyme function 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • Robert D. Ward
    • 1
  1. 1.Department of GeneticsUniversity College of SwanseaSwanseaUnited Kingdom

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