Biochemical Genetics

, Volume 15, Issue 1–2, pp 93–100 | Cite as

Selection against homozygotes in the ADH polymorphic system of Drosophila melanogaster associated with the lethal factor l(2) Stm

  • F. Leibenguth


In the natural populations +Tüb, +Prov, and +Rov, similar AdhF allele frequencies occur (qF=0.11, 0.18, and 0.08, respectively). However, there is a discrepancy in that the AdhF allele in +Tüb is closely linked to the lethal factor 1(2)Stm, which reduces relative fitness of the F phenotype to zero. In spite of this, polymorphism is maintained also in +Tüb, because the heterozygotes are superior to the homozygous S type (relative fitness=0.88). Under laboratory culture conditions, in +Tüb the relative fitness of the S genotype further decreases to 0.6. After outcrossing the lethal factor, relative fitnesses for S, FS, and F become 0.6, 1, and 0.48, respectively, implying that fitness for S remains the same. Relative values for S, FS, and F in +Prov, not affected by the lethal factor, are calculated by the maximum average fitness method to be 1, 1.2, and 0.2 under the assumption that heterozygous FS are similarly superior to S as in the natural +Tüb population and all allele frequencies found are stable equilibrium values.

Key words

alcohol dehydrogenase (ADH) genetic polymorphism selection Drosophila melanogaster 


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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • F. Leibenguth
    • 1
  1. 1.Institut für Genetik der Universität des SaarlandesSaarbrückenWest Germany

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