Abstract
Activities of three lysosomal glycosidases, β-galactosidase, ∐-glucuronidase, and N-acetyl-β-hexosaminidase, have been shown to differ in bf/bf and bf/+ mice. Thus bf/bf mice usually have much higher activities of these enzymes in their kidney cells than bf/+ animals. There seem, however, to be some exceptions to this general pattern, especially for galactosidase of females from the C57BL/6J strain. A likely interpretation of the difference is that the bf locus has pleiotropic effects. An alternative explanation, less likely, is that a gene closely linked to bf is involved. There is also a differential response to dihydrotestosterone in different groups of mice reflected in activity changes of the three enzymes.
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This work was supported by the Hierta Memorial Fund and the Swedish Natural Science Research Council.
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H»kansson, E.M., Lundin, LG. Effect of a coat color locus on kidney lysosomal glycosidases in the house mouse. Biochem Genet 15, 75–85 (1977). https://doi.org/10.1007/BF00484549
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DOI: https://doi.org/10.1007/BF00484549