Abstract
Organ-specific electrophoretic heterogeneity of lysosomal α-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal α-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.
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Supported in part by Grant GM-19521 from the U.S. Public Health Service. One of the authors (M.D.) was supported in part from USPHS Grant TAO-CA05016.
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Dizik, M., Elliott, R.W. A gene apparently determining the extent of sialylation of lysosomal α-mannosidase in mouse liver. Biochem Genet 15, 31–46 (1977). https://doi.org/10.1007/BF00484546
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DOI: https://doi.org/10.1007/BF00484546