Abstract
Isozyme patterns of nucleoside phosphorylase (NP) in 16 inbred strains, two recombinant inbred, one congenic, and three species of wild mice were studied. Evidence is provided for a genetic locus, Np-2, encoding an electrophoretic variant which is expressed exclusively in erythrocytes of certain inbred strains. This finding establishes the occurrence of genetic polymorphism of NP among inbred strains of mice. In addition, the Npl a allele previously reported only in inbred strains has been observed in one of the species of wild mice (Mus musculus castaneus) studied.
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Boyer, S. H., Fainer, D. C., and Naughton, M. A. (1963). Myoglobin inherited structural variation in man. Science 1401228.
Chapman, V. M. (1973). Private communication. Mouse Newsletter 4845.
Edwards, Y. H., Hopkinson, D. A., and Harris, H. (1971). Inherited variants of human nucleoside phosphorylase. Ann. Hum. Genet. 34395.
Fisher, R. A., Putt, W., and Hackel, E. (1976). An investigation of the products of 53 gene loci in three species of wild Canidae: Canis lupus, Canis latrans and Canis familiaris. Biochem. Genet. 14963.
Giblett, E. R., Ammann, A. J., Sandman, R., Wara, D. W., and Diamond, L. K. (1975). Nucleoside phosphorylase deficiency in a child with severely deficient T-cell immunity and normal B-cell immunity. Lancet 11010.
Hirschhorn, R. (1977). Defects of purine metabolism in immunodeficiency diseases. Progr. Clin. Immunol. 367.
Nichols, E. A., and Ruddle, F. H. (1973). A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels. J. Histochem. Cytochem. 211066.
Sandman, R., Amman, A. J., Grose, C., and Wara, D. W. (1977). Cellular immunodeficiency associated with nucleoside phosphorylase deficiency—Immunologic and biochemical studies. Clin. Immun. Immunopathol. 8247.
Staats, J. (1976). Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 364333.
Womack, J. E., Davisson, M. T., Eicher, E. M., and Kendall, D. A. (1977). Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14. Biochem. Genet. 15347.
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This work was supported by a contract from the Council for Tobacco Research, awarded to Microbiological Associates, Bethesda, Maryland.
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Bremner, T.A., Premkumar-Reddy, E., Nayar, K. et al. Nucleoside phosphorylase 2 (Np-2) of mice. Biochem Genet 16, 1143–1151 (1978). https://doi.org/10.1007/BF00484535
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DOI: https://doi.org/10.1007/BF00484535