Chemistry of Heterocyclic Compounds

, Volume 27, Issue 9, pp 986–988 | Cite as

Synthesis of 1,2,4-triazolo[4,3-a]quinoline-9-, 1,2,3,4-tetrazolo[4,3-a]quinoline-9 and 1,2,4-triazino[4,3-a]quinoline-10-carboxylic acids from 2-chloro- and 2-hydrazinocinchoninic acids

  • O. A. Yanborisova
  • M. E. Konshin


Treatment of 2-chlorocinchoninic acid with hydrazine gives 2-hydrazinocinchoninic acid and with aroylhydrazines to give 1,2,4-triazolo[4,3-a]quinoline-9-carboxylic acids. These are also prepared by the action of benzoyl chloride or the carboxylic acid on 2-hydrazinocinchoninic acid. With pyruvic acid the latter gives 3-methyl-4-oxo-1,2,4-triazino[4,3-a]quinoline-10-carboxylic acid and with nitrous acid gives 1,2,3,4-tetrazolo[4,3-a]quinoline-9-carboxylic acid.


Chloride Organic Chemistry Nitrous Acid Carboxylic Acid Hydrazine 
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Literature Cited

  1. 1.
    O. A. Yanborisova and M. E. Konshin, Khim. Geterotsikl. Soedin., No. 4, 493 (1991).Google Scholar

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • O. A. Yanborisova
    • 1
  • M. E. Konshin
    • 1
  1. 1.Perm Pharmaceutical InstitutePerm

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