Abstract
In Mus musculus, family Muridae, the glucosephosphate isomerase (Gpi-1), pink-eyed dilution (p), albinism (c), and β-type globin (Hbb) loci are known to be linked in the order Gpi-1-p-c-Hbb. In Rattus norvegicus, another murid rodent, the p, c, and Hbb loci are known to be linked in the same order and with similar recombination frequencies. In Peromyscus maniculatus, family Cricetidae, it was previously known that p and c are linked and by analogy to Mus musculus that linkage group should be bounded by Gpi-1 near p and by a β-globin locus near c. Linkage has now been established between Gpi-1 and the Hbe globin locus in Peromyscus. However, the observed recombination frequency in Peromyscus (16.3%) is significantly lower than in Mus, suggesting that perhaps a chromosomal inversion has occurred during the evolutionary divergence of the two rodent families. Linkage relationships were also tested between the Hbc 1, Hbd 1, and Hbe 1 globin variants. Hbc 1 (presumably an α-type globin) segregated independently from Hbd 1 and Hbe 1 (presumably β-type globins). No recombination was observed between Hbd 1 and Hbe 1. Those two globin genes may be alleles at a single locus, although circumstantial evidence suggests that they represent tightly linked duplicate loci.
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Avise, J. C., Smith, M. H., Selander, R. K., Lawlor, T. E., and Ramsey, P. R. (1974a). Biochemical polymorphism and systematics in the genus Peromyscus. V. Insular and mainland species of the subgenus Haplomylomys. Syst. Zool. 23226.
Avise, J. C., Smith, M. H., and Selander, R. K. (1974b). Biochemical polymorphism and systematics in the genus Peromyscus. VI. The boylii species group. J. Mammal. 55751.
Avise, J. C., Smith, M. H., and Selander, R. K. (1979). Biochemical polymorphism and systematics in the genus Peromyscus. VII. Geographic differentiation in members of the truei and maniculatus species groups. J. Mammal. 60177.
Castle, W. E., and Wachter, W. L. (1924). Variations of linkage in rats and mice. Genetics 91.
Castle, W. E., and Wright, S. (1915). Two color mutations of rats which show partial coupling. Science 42193.
Clark, F. H. (1936). Linkage of pink-eye and albinism in the deer mouse. J. Hered. 27259.
Davis, B. J. (1964). Disc electrophoresis. II. Method and application to human serum proteins. Ann. N.Y. Acad. Sci. 121404.
DeLorenzo, R. J., and Ruddle, F. H. (1969). Genetic control of two electrophoretic variants of glucosephosphate isomerase in the mouse (Mus musculus). Biochem. Genet. 3151.
Dunn, L. C. (1920). Linkage in mice and rats. Genetics 5325.
Eicher, E. M., and Coleman, D. L. (1977). Influence of gene duplication and X-inactivation on mouse mitochondrial malic enzyme activity and electrophoretic patterns. Genetics 85647.
Flavell, R. A., Kooter, J. M., and DeBoer, E. (1978). Analysis of the β-δ-globin gene loci in normal and Hb Lepore DNA: Direct determination of gene linkage and intergene distance. Cell 1525.
French, E. A., Roberts, K. B., and Searle, A. G. (1971). Linkage between a hemoglobin locus and albinism in the Norway rat. Biochem. Genet. 5397.
Gilman, J. G. (1974). Rodent hemoglobin structure: A comparison of several species of mice. Ann. N.Y. Acad. Sci. 241416.
Gilman, J. G. (1976). Mouse haemoglobin beta chains: Sequence data on embryonic y chain and genetic linkage of the y-chain locus to the adult β-chain locus Hbb. Biochem. J. 155231.
Harris, H., and Hopkinson, D. A. (1977). Handbook of Enzyme Electrophoresis in Human Genetics North-Holland, Amsterdam.
Hutton, J. J. (1969). Linkage analyses using biochemical variants in mice. I. Linkage of the hemoglobin beta-chain and glucosephosphate isomerase loci. Biochem. Genet. 3507.
Hutton, J. J., Bishop, J., Schweet, R., and Russell, E. S. (1962). Hemoglobin inheritance in inbred mouse strains. II. Genetic studies. Proc. Natl. Acad. Sci. 481718.
Lalley, P. A., Francke, U., and Minna, J. D. (1978a). Homologous genes for enolase, phosphogluconate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome 1p. Proc. Natl. Acad. Sci. 752382.
Lalley, P. A., Minna, J. D., and Francke, U. (1978b). Conservation of autosomal gene synteny groups in the mouse and man. Nature 274160.
Mainland, D., Herrera, L., and Sutcliffe, M. I. (1956). Statistical Tables for Use with Binomial Samples—Contingency Tests, Confidence Limits, and Sample Size Estimates, Department of Medical Statistics, New York University College of Medicine, New York.
Maybank, K. M., and Dawson, W. D. (1976). Genetic and developmental variation of hemoglobin in the deer mouse, Peromyscus maniculatus. Biochem. Genet. 14389.
McKusick, V. A., and Ruddle, F. H. (1977). The status of the gene map of the human chromosomes. Science 196390.
Mitchell, N. J. (1977). Genetic variation in populations of Peromyscus maniculatus in northwestern Montana, masters dissertation, University of Montana.
Morizot, D. C., Wright, D. A., and Siciliano, M. J. (1977). Three linked enzyme loci in fishes: Implications on the evolution of vertebrate chromosomes. Genetics 86645.
Ohno, S. (1973). Ancient linkage groups and frozen accidents. Nature 244259.
Padua, R. A., Bulfield, G., and Peters, J. (1978). Biochemical genetics of a new glucosephosphate isomerase allele (Gpi-1 c) from wild mice. Biochem. Genet. 16127.
Popp, R. A., and Bailiff, E. G. (1973). Sequence of amino acids in the major and minor β-chains of the diffuse hemoglobin from BALB/c mice. Biochim. Biophys. Acta 30361.
Popp, R. A., and St. Amand, W. (1960). Studies on the mouse hemoglobin loci. I. Identification of hemoglobin types and linkage of hemoglobin with albinism. J. Hered. 51141.
Robinson, R. (1964). Linkage in Peromyscus. Heredity 19701.
Rucknagel, D. L., and Winter, W. P. (1974). Duplication of structural genes for hemoglobin α and β chains in man. Ann. N.Y. Acad. Sci. 24180.
Russell, E. S., and McFarland, E. C. (1974). Genetics of mouse hemoglobins. Ann. N.Y. Acad. Sci. 24125.
Selander, R. K., Smith, M. H., Yang, S. Y., Johnson, W. E., and Gentry, J. B. (1971). Biochemical polymorphism and systematics in the genus Peromyscus. I. Variation in the old-field mouse (Peromyscus polionotus). Univ. Texas Publ. 7103 Stud. Genet. 649.
Skow, L. C. (1978). Genetic variation at a locus (Tam-1) for submaxillary gland protease in the mouse and its location on chromosome 7. Genetics 90713.
Snyder, L. R. G. (1978a). Genetics of hemoglobin in the deer mouse, Peromyscus maniculatus. I. Multiple α- and β-globin structural loci. Genetics 89511.
Snyder, L. R. G. (1978b). Genetics of hemoglobin in the deer mouse, Peromyscus maniculatus. II. Multiple alleles at regulatory loci. Genetics 89531.
Weaver, S. G., Haigwood, N. L., Hutchison, C. A., III, and Edgell, M. H. (1978). DNA fragments of the Mus musculus β globin haplotypes Hbb s and Hbb d. Proc. Natl. Acad. Sci. 761385.
Womack, J. E., and Sharp, M. (1976). Comparative autosomal linkage in mammals: Genetics of esterases in Mus musculus and Rattus norvegicus. Genetics 82665.
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This work was supported by NSF DEB7716104 and by the Committee on Research, UCR.
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Snyder, L.R.G. Evolutionary conservation of linkage groups: Additional evidence from murid and cricetid rodents. Biochem Genet 18, 209–220 (1980). https://doi.org/10.1007/BF00484237
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DOI: https://doi.org/10.1007/BF00484237