Abstract
C3 phenotypes were examined in species of Papio and Macaca. Baboons (P. cynocephalus) showed extensive polymorphism, with estimated gene frequencies of 0.815, 0.174, and 0.011 for C3*S, C3*F, and C3*F 1 alleles, respectively. Clear segregation patterns showing codominant inheritance were evident in family studies. Such extensive polymorphism was not observed in M. nemestrina or M. fascicularis. The S gene is the most common allele in all the species studied. The F gene is relatively common in baboons.
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References
Alper, C. A., and Johnson, A. M. (1969). Immunofixation electrophoresis: A technique for the study of protein polymorphism. Vox Sang. 17445.
Alper, C. A., and Propp, R. P. (1967). Genetic polymorphism of the third component of human complement C'3). J. Clin. Invest. 472181.
Alper, C. A., and Rosen, F. S. (1976). Genetics of complement system. Adv. Hum. Genet. 1141.
Alper, C. A., Robin, N. I., and Refeloff, S. (1971). Genetic polymorphism in rhesus C3 and Gc globulin. J. Immunol. 10796.
Alper, C. A., Azen, E. A., Geserick, G., Goedde, H. W., Rittner, C., Teisberg, P., and Wieme, R. (1973). Statement on the polymorphism of the third component of complement in man (C3). Vox Sang. 2518.
Azen, E. A., and Smithies, O. (1968). Genetic polymorphism of C'3 (βIC-globulin) in human serum. Science 162905.
Brönnestam, R. (1973). Studies of the C3 polymorphism. Relationship between C3 phenotypes and rheumatoid arthritis. Hum. Hered. 23206.
Dissing, J., Lund, J., and Sørensen, H. (1972). C3 polymorphism in a group of old arteriosclerotic patients. Hum. Hered. 22466.
Farhud, D. D., Ananthakrishnan, R., and Walter, H. (1972). Association between C3 phenotypes and various diseases. Humangentik 1757.
McMahan, M. R. (1981). Studies of the genetic polymorphism of the third component of complement (C3) in nonhuman primates. Am. J. Primatol. 1320 (abstr).
Napier, J. R. (1970). Paleoecology and catarrhine evolution. In Napier, J. R., and Napier, P. H. (eds.), Old World Monkeys. Evolution, Systematics and Behavior Academic Press, New York.
Raum, D., Balner, H., Petersen, B. H., and Alper, C. (1980). Genetic polymorphism of serum complement components in the chimpanzee. Immunogenetics 10455.
Rittner, C., and Rittner, B. (1974). Report 1973/74 of the Reference Laboratory for the Polymorphism of the Third Component (C'3) of the Human Complement System. Vox Sang. 27464.
Rose, M., and Geserick, G. (1969). Ein neuer Serumproteinpolymorphismus: Pt erste Hinweise für eine genetische Steuerung. Acta Biol. Med. Germ. 23351.
Scheffrahn, W., Biedermann, V., and Rauch-Schwegler, T. (1979). Agarose gel electrophoretic position of IC-globulin (C3) in primates. J. Hum. Evol. 8315.
Shows, T. B., Alper, C. A., Bootsma, D., Dorf, M., Douglas, T., Huisman, T., Kit, S., Klinger, H. P., Kozak, C., Lalley, P. A., Lindsley, D., McAlpine, P. J., McDougall, J. K., Meera Khan, P., Meisler, M., Morton, N. E., Opitz, J. M., Partridge, C. W., Payne, R., Roderick, T. H., Rubinstein, P., Ruddle, F. H., Shaw, M., Spranger, J. W., and Weiss, K. (1979). International System of Human Gene Nomenclature (1979). Cytogenet. Cell Genet. 2596.
Sørensen, H., and Dissing, J. (1975). Association between the C3F gene and atherosclerotic vascular disease. Hum. Hered. 25279.
Teisberg, P. (1970). High voltage agarose gel electrophoresis in the study of C3 polymorphism. Vox Sang. 1947.
Wieme, R. J. (1965). Agar Gel Electrophoresis Elsevier, Amsterdam.
Wieme, R. J., and Demeulenaere, L. (1967). Genetically determined electrophoretic variant of human complement component. Nature 2141042.
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This work was supported by NIH Grant RR00166 to the Regional Primate Research Center at the University of Washington.
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Bulusu, L.K., Clark, E.A. Genetic polymorphism of C3 in Papio and Macaca species. Biochem Genet 20, 859–864 (1982). https://doi.org/10.1007/BF00484063
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DOI: https://doi.org/10.1007/BF00484063