Biochemical Genetics

, Volume 4, Issue 1, pp 1–9 | Cite as

Heterogeneity of phosphoglucomutase

  • David M. Dawson
  • Susan Jaeger


A survey of the isoenzyme patterns of phosphoglucomutase (PGM) as demonstrated by starch gel electrophoresis has been undertaken in different species. Seven mammals, two birds, one reptile, two amphibians, four fish, and four invertebrates were studied, and in some cases several tissues were examined. In all cases the predominant enzyme present was a group of electrophoretically related enzymes which are believed to all represent expression of the PGM1 allele. In some species, examples of other groups of isoenzymes were encountered, presumably representing other genetic loci, corresponding to PGM2 and PGM3. These were always less in amount. The PGM from the chicken was unique in the survey in that its mobility changed with storage. A somewhat similar although not identical change could be produced by addition of PCMB to the partially purified enzyme. Both altered enzymes, i.e., that resulting from storage and that produced by addition of PCMB, were more heat labile.


Starch Genetic Locus Related Enzyme Identical Change Phosphoglucomutase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cahn, R. D., Kaplan, N. O., Levine, L., and Zwilling, E. (1962). The nature and development of lactic dehydrogenases. Science 136 962.Google Scholar
  2. Coifman, R. E., and Epstein, C. J. (1969). Human red cell phosphoglucomutase; isoenzyme fractionation and labeling studies. Federation Proc. 28 843 (abst.).Google Scholar
  3. Dawson, D. M., and Mitchell, A. (1969). The isoenzymes of phosphoglucomutase. Biochemistry 8 609.Google Scholar
  4. Dawson, D. M., Eppenberger, H. M., and Eppenberger, M. E. (1968). Multiple molecular forms of creatine kinases. Ann. N.Y. Acad. Sci. 151 616.Google Scholar
  5. Epstein, C. J., and Schechter, A. N. (1968). An approach to the problem of conformational isoenzymes. Ann. N.Y. Acad. Sci. 151 85.Google Scholar
  6. Harshman, S., Robinson, J. P., Bocchini, V., and Najjar, V. A. (1965). Activation of phosphoglucomutase. Biochemistry 4 396.Google Scholar
  7. Hopkinson, D. A., and Harris, H. (1965). Evidence for a second “structural” locus determining human phosphoglucomutase. Nature 208 410.Google Scholar
  8. Hopkinson, D. A., and Harris, H. (1966). Rare phosphoglucomutase phenotypes. Ann. Human Genet. 31 359.Google Scholar
  9. Hopkinson, D. A., and Harris, H. (1968). A third phosphoglucomutase locus in man. Ann. Human Genet. 31 359.Google Scholar
  10. Joshi, J. G., Hooper, J., Kuwaki, T., Sakurada, T., Swanson, J. R., and Handler, P. (1967). Multiple forms of phosphoglucomutase. Proc. Natl. Acad. Sci. 56 578.Google Scholar
  11. Kitto, G. B., Wasserman, P. M., and Kaplan, N. O. (1966). Enzymatically active conformers of mitochondrial malate dehydrogenase. Proc. Natl. Acad. Sci. 56 578.Google Scholar
  12. Parrington, J. M., Craickshank, G., Hopkinson, D. A., Robson, E. B., and Harris, H. (1968). Linkage relationships between three phosphoglucomutase lcci PGM1, PGM2, and PGM3. Ann. Human Genet. 32 27.Google Scholar
  13. Rutter, W. J., Rajkumar, T., Penhoet, E., and Kochman, M. (1968). Aldolase variants: Structure and physiological significance. Ann. N.Y. Acad. Sci. 151 102.Google Scholar
  14. Shows, T. B., Ruddle, F. H., and Roderick, T. H. (1969). Phosphoglucomutase electrophoretic variants in the mouse. Biochem. Genet. 3 25.Google Scholar
  15. Spencer, N. A., Hopkinson, D. A., and Harris, H. (1964). Phosphoglucomutase polymorphism in man. Nature 204 742.Google Scholar
  16. Yankeelov, J. A., Jr., Horton, H. R., and Koshland, D. E., Jr. (1964). A chromatographic study of phosphoglucomutase: Separation of phospho- and dephospho-enzyme forms. Biochemistry 3 349.Google Scholar

Copyright information

© Plenum Publishing Corporation 1970

Authors and Affiliations

  • David M. Dawson
    • 1
    • 2
  • Susan Jaeger
    • 1
    • 2
  1. 1.Department of NeurologyHarvard Medical SchoolCambridge
  2. 2.Peter Bent Brigham HospitalBoston

Personalised recommendations