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Biochemical Genetics

, Volume 4, Issue 1, pp 1–9 | Cite as

Heterogeneity of phosphoglucomutase

  • David M. Dawson
  • Susan Jaeger
Article

Abstract

A survey of the isoenzyme patterns of phosphoglucomutase (PGM) as demonstrated by starch gel electrophoresis has been undertaken in different species. Seven mammals, two birds, one reptile, two amphibians, four fish, and four invertebrates were studied, and in some cases several tissues were examined. In all cases the predominant enzyme present was a group of electrophoretically related enzymes which are believed to all represent expression of the PGM1 allele. In some species, examples of other groups of isoenzymes were encountered, presumably representing other genetic loci, corresponding to PGM2 and PGM3. These were always less in amount. The PGM from the chicken was unique in the survey in that its mobility changed with storage. A somewhat similar although not identical change could be produced by addition of PCMB to the partially purified enzyme. Both altered enzymes, i.e., that resulting from storage and that produced by addition of PCMB, were more heat labile.

Keywords

Starch Genetic Locus Related Enzyme Identical Change Phosphoglucomutase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1970

Authors and Affiliations

  • David M. Dawson
    • 1
    • 2
  • Susan Jaeger
    • 1
    • 2
  1. 1.Department of NeurologyHarvard Medical SchoolCambridge
  2. 2.Peter Bent Brigham HospitalBoston

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