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α1-Antitrypsin polymorphism in Malaysian Macaca irus

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Abstract

α1-Antitrypsin types were determined in 200 individual specimens of Malaysian Macaca irus. We found the pattern B in 76 samples, BC in 116, and C in 8. Assuming that these patterns are determined by codominant alleles at one locus, this distribution constitutes a significant (P<0.001) deviation from Hardy-Weinberg equilibrium, because of an excess of BC and low prevalence of C. We found no clear evidence for the presence of α1-antitrypsin deficiency comparable to the situation in man.

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Author notes

  1. F. Kueppers

    Present address: Temple University School of Medicine, Philadelphia, Pennsylvania

Authors and Affiliations

  1. Mayo Clinic and Mayo Foundation, Rochester, Minnesota

    F. Kueppers

  2. Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia

    J. Ganesan

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  1. F. Kueppers
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  2. J. Ganesan
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Additional information

Supported in part by Grant HL-16752 from the National Heart, Lung, and Blood Institute.

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Kueppers, F., Ganesan, J. α1-Antitrypsin polymorphism in Malaysian Macaca irus . Biochem Genet 15, 817–823 (1977). https://doi.org/10.1007/BF00483978

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  • DOI: https://doi.org/10.1007/BF00483978

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