Abstract
Nucleoside transport in sheep erythrocytes is under the genetic control of two allelomorphic genes (Nu I and Nu i), where Nu I codes for the functional absence of a high-affinity nucleoside transport system and is dominant to the gene (Nu i) coding for the presence of the transport system. Kinetic and inhibitor experiments show that the high-affinity transport system is not present in heterozygous erythrocytes, demonstrating that the Nu I gene is completely dominant over the Nu i gene. It is suggested that the Nu locus may not represent the structural gene locus of the nucleoside transport system. Instead, it may be a regulator gene locus.
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S. M. J. is the recipient of an MRC postgraduate studentship.
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Jarvis, S.M., Young, J.D. Genetic control of nucleoside transport in sheep erythrocytes. Biochem Genet 16, 1035–1043 (1978). https://doi.org/10.1007/BF00483754
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DOI: https://doi.org/10.1007/BF00483754