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Chemistry of Heterocyclic Compounds

, Volume 13, Issue 4, pp 417–420 | Cite as

Synthesis and properties of some pyrimido[5,4-d]pyrimidine derivatives

  • N. E. Britikova
  • A. S. Elina
Article
  • 31 Downloads

Abstract

A method for the preparation of 2,4,8-trioxo-6-methyl derivatives of pyrimido[5,4-d]pyrimidine with various alkyl residues in the 7 position is described. It is shown that the chlorine in the 4 position of the 2,4-dichloro derivative of pyrimido[5,4-d]pyrimidine is the most labile in nucleophilic substitution reactions.

Keywords

Organic Chemistry Chlorine Pyrimidine Nucleophilic Substitution Substitution Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

  1. 1.
    H. Spitzbarth, Arzneimittel-Forsch., 9, 59 (1959).Google Scholar
  2. 2.
    F. G. Fischer and J. Roch, Ann., 572, 217 (1951).Google Scholar
  3. 3.
    N. E. Britikova, L. A. Belova, K. A. Chkhikvadze, and O. Yu. Magidson, Khim. Geterotsikl. Soedin., No 2, 270 (1973).Google Scholar
  4. 4.
    Masuo Murakami, Shigemi Kawahara, Sanae Ishida, Mikio Ohno, and Hiroshi Horigychi, US patent No. 3,562,265 (1971); Ref. Zh. Khim., 21N, 470 (1971).Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • N. E. Britikova
    • 1
  • A. S. Elina
    • 1
  1. 1.S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry InstituteMoscow

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