Chemistry of Heterocyclic Compounds

, Volume 13, Issue 4, pp 417–420 | Cite as

Synthesis and properties of some pyrimido[5,4-d]pyrimidine derivatives

  • N. E. Britikova
  • A. S. Elina


A method for the preparation of 2,4,8-trioxo-6-methyl derivatives of pyrimido[5,4-d]pyrimidine with various alkyl residues in the 7 position is described. It is shown that the chlorine in the 4 position of the 2,4-dichloro derivative of pyrimido[5,4-d]pyrimidine is the most labile in nucleophilic substitution reactions.


Organic Chemistry Chlorine Pyrimidine Nucleophilic Substitution Substitution Reaction 
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Literature cited

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Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • N. E. Britikova
    • 1
  • A. S. Elina
    • 1
  1. 1.S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry InstituteMoscow

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