Chemistry of Heterocyclic Compounds

, Volume 13, Issue 4, pp 408–409 | Cite as

Research on 2,3-polymethylenequinolines

XXI Ionization constants of 4-chloro-6-R-2,3-polymethylenequinolines
  • M. E. Konshin
  • É. S. Abramochkin
  • D. I. Uvarov


The ionization constants of 4-chloro-6-R-2,3-polymethylenequinolines in 98% methanol were found and it was established that they correlate with the σepi substituent constants for quinoline. It is shown that the pK a values of 2,3-tetra- and 2,3-pentamethylenequinolines are close to one another, whereas the pK a values of 2,3-trimethylenequinolines are one order of magnitude lower; this is a result of the angular strain in the ring system of the latter.


Methanol Organic Chemistry Quinoline Ring System Ionization Constant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Literature cited

  1. 1.
    M. E. Konshin, Khim. Geterotsikl. Soedin., No. 7, 966 (1974).Google Scholar
  2. 2.
    J. H. Margraf and W. Scott, Chem. Commun., No. 6, 296 (1967).Google Scholar
  3. 3.
    A. Albert, J. Chem. Soc., 4653 (1965).Google Scholar
  4. 4.
    M. E. Konshin and D. I. Uvarov, Khim. Geterotsikl. Soedin., No. 4, 531 (1973).Google Scholar
  5. 5.
    D. I. Uvarov, M. E. Konshin, A. S. Zaks, L. G. Zilbermints, and T. A. Kapitonenko, Khim.-farm. Zh., No. 8, 25 (1973).Google Scholar
  6. 6.
    A. P. Terent'ev and V. M. Potapov, Fundamentals of Stereochemistry [in Russian], Khimiya, Moscow-Leningrad (1964), p. 127.Google Scholar
  7. 7.
    E. Baciochi, G. Illuminati, and G. Marino, J. Am. Chem. Soc., 80, 2270 (1958).Google Scholar
  8. 8.
    E. Baciochi and G. Illuminati, Gazz. Chim. Ital., 137, 981 (1957).Google Scholar
  9. 9.
    M. E. Konshin, D. I. Uvarov, and É. S. Abramochkin, Khim. Geterotsikl. Soedin., No. 8, 1106 (1974).Google Scholar

Copyright information

© Plenum Publishing Corporation 1977

Authors and Affiliations

  • M. E. Konshin
    • 1
  • É. S. Abramochkin
    • 1
  • D. I. Uvarov
    • 1
  1. 1.Perm Pharmaceutical InstitutePerm

Personalised recommendations