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Die Beteiligung der mesenchymalen Zellen (Lymphocyten und Monocyten) bei der Entstehung der Hautsensibilisierung der Meerschweinchen mit Dinitrochlorbenzol

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Zusammenfassend

Im Verlaufe der Sensibilisation der Meerschweinchen steigt die RNS in der Haut und in der Leber an, dagegen nicht in der Milz; der DNS-Gehalt ändert sich in allen untersuchten Organen praktisch nicht.

Wenn auch unsere Ergebnisse, der kleinen Anzahl von Tieren wegen, nur eine beschränkte Gültigkeit haben, bestätigen sie doch unsere Ansichten über die Erhöhung der Lymphocyten in der Haut und über ihre intensivere Produktion in der Leber. Die Erhöhung der RNS in der Leber kann auch wahrscheinlich als Folge einer Aktivierung der Leber-RES-Zellen, die bei der Sensibilisierung eine wichtige Rolle in der Produktion der Antikörper respektive als Träger der Antikörpereigenschaften spielen, angesehen werden.

Daß wir keine Veränderungen der DNS in den untersuchten Organen fanden, entspricht den Angaben von Kedrovskij (1951), welcher feststellen konnte, daß die Veränderungen der DNS verhältnismäßig seltener vorkommen als die Veränderungen der RNS, die sich an den biologischen Prozessen viel mehr beteiligt.

Selbstverständlich müssen unsere Ergebnisse an einem größeren Material bestätigt und insbesondere die Rolle der Nucleinsäuren bei der ekzematösen Sensibilisation eingehender analysiert werden. Auch die reflektorische Steuerung des Nucleinsäure-Stoffwechsels in der Haut und anderen Geweben beim Sensibilisationsprozeß sollte noch Gegenstand weiterer Forschungen werden.

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Literatur

  • Andreasen, E.: On the occurence of lymphocytes in the normal epidermis. Acta dermato-vener. (Stockh.) Suppl. 29, 17 (1952).

    Google Scholar 

  • Andreasen, E., and Haxthausen, H.: Lymph node response to cutaneous sensitisation with DNCB. Acta path. scand., (Copenh.) 29, 345 (1951).

    Google Scholar 

  • Andrew, W.: The role of lymphocytes in the normal epidermis. Anat. Rec. 103, 419 (1949).

    Google Scholar 

  • Andrew, W., and N. V. Andrew: Lymphocytes in the normal epidermis of the rat and of man. Anat. Rec. 104, 217 (1949). Azleckaja-Macievskaja, N. E.: zit. J. Šterzl 1954.

    Google Scholar 

  • Baer, R. L., and M. B. Sulzberger: Attempts at passive transfer of allergic eczematous sensitivity in man. J. Invest. Dermat. 18, 53 (1952).

    Google Scholar 

  • Belisario, J. C.: The pathogenesis of eczema. Excerpta Med., Sect. XIII. 6, 282 (1952).

    Google Scholar 

  • Bennet, I. L.: Comparison of leucocyte changes, produced by pyrogens and by anaphylaxis in the guinea pig. Proc. Soc. Exper. Biol. a. Med. 77, 772 (1951).

    Google Scholar 

  • Biedl, A.: Experimentelle Studien über Anaphylaxie. Wien. klin. Wschr., 1909, 363.

  • Bircher, W.: Dermat. Z. 45, 271 (1925).

    Google Scholar 

  • Bloch, Br.: Z. exper. Path. u. Ther. 9, 509 (1911).

    Google Scholar 

  • Brain, R. T.: Pathogenesis of infantile eczema. Excerpta Med., Sect. XIII. 6, 303 (1952).

    Google Scholar 

  • Bruun, E.: The histopathology of allergic skin reactions. Acta path. scand. (Copenh.) 18, 558 (1941).

    Google Scholar 

  • Buchwald, H.: Untersuchungen über den Einfluß des sensiblen Nervensystoms auf die Pathogenese allergischer Hauterkrankungen. Med. Klin. 1940, 1032.

  • Cohen, S. G. et al.: The effect of X-radiation on experimentally produced cutaneous sensitivity. J. Invest. Dermat. 16, 91 (1952).

    Google Scholar 

  • Cordonnier, V.: Etudes histo-chimique de l'intolerance cutanée dans eczéma expérimental. Arch. belges Derm. 5, 321 (1949).

    Google Scholar 

  • Crepea, S. B., and R. A. Cooke: Study on the mechanism of dermatitis venenata in the guinea pig with a demonstration of skin-sensitizing antibody by passive transfer. J. Allergy, 19, 353 (1948).

    Google Scholar 

  • Cruickshank, J.: Anti-lymphocytic serum. Brit. J. Exper. Path. 22, 126 (1941).

    Google Scholar 

  • Cummings, M. M. et al.: Passive transfer of tuberculin sensitivity in the guinea pig. Publ. Health Rep. 1947, 994.

  • Curtis, G. H.: An attempt to demonstrate antibodies in eczematous contact type-dermatitis. Arch. of Dermat. 65, 149 (1952).

    Google Scholar 

  • Czezowska, Z., et T. Gamuszewski: O reaginach tuberkulinovych w sledzionie morskiej swińki, zaszczepionej BCG. Polski Tygodnik Lek. 5, 808 (1950).

    Google Scholar 

  • David, M.: Das lokale Blutbild von Hautkrankheiten. Orv. Hetil. 1938, 1066.

  • Davidson, J. N.: The biochemistry of the nucleic acids. 1950.

  • Dianzani, M. U.: Modificazioni del contenuto in acidi nucleinici del sangue e dei tessuti in rapporto allo stato immunitario. Riv. Ist. sieroter. ital. 25, 9 (1950).

    Google Scholar 

  • Dougherty, T. F. et al.: The demonstration of antibodies in lymphocytes. Proc. Soc. Exper. Biol. a. Med. 57, 295 (1944).

    Google Scholar 

  • Ehrich, W. E., and T. N. Harris: The formation of antibodies in the popliteal lymph node in rabbits. J. of. Exper. Med. 76, 335 (1942).

    Google Scholar 

  • Ehrich, W. E. et al.: Nucleic acid and the production of antibody by plasma cells. J. of Exper. Med. 90, 157 (1949).

    Google Scholar 

  • Fawour, C. B.: Lytic effect of bacterial products on lymphocytes of tuberculous animals. Proc. Soc. Exper. Biol. a. Med. 65, 269 (1947).

    Google Scholar 

  • Fawour, C. B. et al.: Factors affecting the in vitro cytolysis of white blood cells by tuberculin. Amer. Rev. Tbc. 60, 212 (1949).

    Google Scholar 

  • Fischer, K.: Zur Cytologie der Exsudate bei Ekżemkrankheiten. Dermat. Wschr. 1953, 768.

  • Fremont-Smith, P., and C. B. Fawour: In vitro lysis of leukocytes from tuberculous humans by tuberculoproteid. Proc. Soc. Exper. Biol. a. Med. 67, 502 (1948).

    Google Scholar 

  • Hagerman, G.: How is epidermal hypersensitivity transmitted through the lymphocytes. Excerpta Med. Sect. XIII. 6, 285 (1952).

    Google Scholar 

  • Harris, T. N. et al.: The role of the lymphocytes in antibody formation. J. of Exper. Med. 80, 73 (1944).

    Google Scholar 

  • Harris, T. N., and S. Harris: Histological changes in lymphocytes during the production of antibodies in lymph nodes of rabbits.

  • Haxthausen, H.: The pathogenesis of allergic eczema elucidated by transplantation experiments on identical twins. Acta dermato-vener. (Stockh.) 23, 438 (1943).

    Google Scholar 

  • : The occurence of humoral antibodies in allergic eczema investigated through parabiosis experiments on guinea pigs. Acta dermato-verner. (Stockh.) 24, 286 (1943).

    Google Scholar 

  • : Studies on the role of the lymphocytes as “transmitter” of the hypersensitivenes in allergic eczeima. Acta dermato-vener. (Stockh.) 27, 275 (1947).

    Google Scholar 

  • : The pathogenesis of allergic eczema, illustrated by transplantation experiments. Acta dermato-vener. (Stockh.) 31, 42 (1951).

    Google Scholar 

  • : Passive transmission of dinitrochlorbenzen allergy with white blood cells from sensitized guinea pigs. Acta dermato-vener. (Stockh.) 31, 659 (1951).

    Google Scholar 

  • : Experiments on passive transfer of eczematous allergy. J. Invest. Dermat. 19, 293 (1952).

    Google Scholar 

  • : “Antistofferne” ved allergisk eczem. Nord. Med. 49, 81 (1953).

    Google Scholar 

  • : Attempts on passive local sensitization by intracutaneous injection of cells from freshly excided lymph nodes of eczema allergies. J. Invest. Dermat. 21, 237 (1953).

    Google Scholar 

  • Hellerström, S.: Allergy of the skin. Acta dermato-vener. (Stockh.) suppl. 29, 150 (1952).

    Google Scholar 

  • Charpy, J., et L. Oddoze: La théorie immunologique classique de l'eczéma. Semaine Hôp. 1953, 54.

  • Chase, M. W.: The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc. Soc. Exper. Biol. a. Med. 59, 134 (1945).

    Google Scholar 

  • : The cellular transfer of cutaneous hypersensitivity. J. Bacter. 51, 643 (1946).

    Google Scholar 

  • : Development of antibody following transfer of cells taken from lymph nodes of sensitized or immunized animals. Federat. Proc. 10, 1 (1951).

    Google Scholar 

  • Kedrovskij, B. V.: Ribonukleinovaja kislota i jeje rol v razvitii i funkcii kletki. Uspechi. Sovrem. Biol., 31, 38 (1951).

    Google Scholar 

  • : Nukleinovije kisloty v kletkach povreždennogo i bolnogo organisma. Uspechi Sovrem. Biol., 31, 309 (1951).

    Google Scholar 

  • Kinsell, L. W., et al.: Blood constituents during anaphylactic shock in monkey. J. of Immun. 42, 35 (1941).

    Google Scholar 

  • Kirschheimer, W. F. et al: Tuberculin reaction. III. Transfer of systemic tuberculin sensitivity with cells of tuberculous guinea pigs. Proc. Soc. Exper. Biol. a. Med. 70, 99 (1949).

    Google Scholar 

  • Klausner, E.: Über seltene Formen echter Arzneiüberempfindlichkeit. Dermat. Wschr. 63, 803 (1916).

    Google Scholar 

  • Knowles, R., et al: Arch. of Dermat. 33, 227 (1936).

    Google Scholar 

  • Landsteiner, K., and M. W. Chase: Experiments on transfer of cutaneous sensitivity to simple compounds. Proc. Soc. Exper. Biol. a. Med. 49, 688 (1942).

    Google Scholar 

  • Lawrence, H. S.: The cellular transfer of cutaneous type sentitivity to tuberculin in man. Proc. Soc. Exper. Biol. a. Med. 71, 516 (1949).

    Google Scholar 

  • Leider, M., and R. L. Baer: The present status of passive transfer of antibodies in allergic eczematous contact-type dermatitis. J. Invest. Dermat. 10, 425 (1948).

    Google Scholar 

  • Lowemann, J.: J. Amer. Med. Assoc. 102, 97 (1934).

    Google Scholar 

  • Makinodan, T., et al.: Nucleic acid changes in spleen during precipitin production in chickens. Federat. Proc. 12, 453 (1953).

    Google Scholar 

  • Mallinckrodt-Haupt, F.: Hautentzündung und Funktionsstörungen innerer Organe. Arch. f. Dermat. 191, 129 (1950).

    Google Scholar 

  • McMaster, P. D., and S. S. Hudack: The formation of agglutinins within lymph nodes. J. of Exper. Med. 61, 783 (1935).

    Google Scholar 

  • McMaster, P. D., et S. Kidd: 1937. zit. J. Šterzl 1954.

  • Metaxas, N. N., and M. Metaxas-Buhler: Passive transfer of local cutaneous hypersensitivity to tuberculin. Proc. Soc. Exper. Biol. a. Med. 69, 163 (1948).

    Google Scholar 

  • Miescher, G.: Histologie der allergischen Reaktionen. I. Intern. Allergiekongreß. Zürich 1951.

  • : Zur Histologie der ekzematösen Kontaktreaktion. Dermatologica (Basel) 104, 215 (1952).

    Google Scholar 

  • Miller, J. M.: A plasma factor responsible for in vitro lysis of leukocytes by tubereuloprotein. Proc. Soc. Exper. Biol. a. Med. 70, 738 (1949).

    Google Scholar 

  • Miller, J. M., et al: The role of complement in the lysis of leukocytes by tuberculoprotein. Proc. Soc. Exper. Biol. a. Med. 71, 592 (1949).

    Google Scholar 

  • Murphy, J. B., and E. Sturm: A comparison of the effect of X-rays and dry heat on antibody formation. J. of Exper. Med. 41, 245 (1925).

    Google Scholar 

  • Nägeli, O., et al: Nachweis des cellulären Sitzes der Allergie beim fixen Antipyrinexanthem. Klin. Wschr. 1930, 924.

  • Nexmand, P. H.: The cellular content of exudates from eczematous and toxic patch test reactions. J. Invest. Dermat. 13, 85 (1949).

    Google Scholar 

  • : Skin sensitization to nitrogen mustard with reference to the cytologic differences between primary irritant and eczematous reactions. Dermatologica (Basel) 100, 73 (1950).

    Google Scholar 

  • Polák, L.: Analysa afferentního článku reflexního oblouku při sensibilisaci kůže na dinitrochlorbenzol u morěte. Csl. Fysiologie, 4, 186 (1955).

    Google Scholar 

  • : Analysa eferentního článku reflexního oblouku při sensibilisaci kůže morčete na dinitrochlorbenzol. Čsl. Fysiologie 4, 309 (1955).

    Google Scholar 

  • : Síření sensibilisace kůže na dinitrochlorbenzol po myelotomii, Čsl Fysiologie, 4, 315 (1955).

    Google Scholar 

  • Rich, A. R., and M. R. Lewis: Proc. Soc. Exper. Biol. a Med. 25, 596 (1927–28).

    Google Scholar 

  • Rostenberg, A. jun.: Eczematous sensitization. A review of its immunologic properties and some speculations as to its nature. Arch of Dermat. 56, 222 (1947).

    Google Scholar 

  • jun.: Studies in eczematous sensitization. V. The role of the regional lymph node. Arch. of Dermat. 72, 221 (1955).

    Google Scholar 

  • Sacharov, P. P., et al: Laboratornye životnye, Moskva 1952.

  • Seeberg, G.: Eczematogeness sensitization via the lymphatic glands. Acta dermato-vener. (Stockh.) 31, 592 (1951).

    Google Scholar 

  • : Studies of the peripheral white blood count in guinea pigs sensitized to 2,4, dinitrochlorbenzen. Acta dermato-vener. (Stockh.) 33, 359 (1953).

    Google Scholar 

  • Schneider, J.: J. of Biol. Chem. 161, 293 (1945).

    Google Scholar 

  • Spear, F.: Determination of antibody content of lymphoid cell extracts. J. Labor. a. Clin. Med. 33, 1563 (1948).

    Google Scholar 

  • Stavitsky, A. B.: Passive cellular transfer of the tuberculin typ of hypersensitivity. Proc. Soc. Exper. Biol. a. Med. 67, 225 (1948).

    Google Scholar 

  • Stavitsky, F.: Role of popliteal lymph node cells and splenic cells in synthesis of diphteria antitoxin.

  • Sulzberger, M. B., and F. Wise: Arch. of Dermat. 27, 549 (1933).

    Google Scholar 

  • Šmahel, O. et R. Šmahelová: Vliv dusíkatého yperitu na tvorhu protilátek. Čas. Lék. čes. 91, 733 (1952).

    Google Scholar 

  • Šterzl, J.: Imunobiologické pochody v průběhu experimentální tuberkulosy. Čsl. Biologie 1, 275 (1952).

    Google Scholar 

  • Šterzl, J.: Obranné pochody v organismu, Praha 1954.

  • Tzank, R., et al: Etude critique de certains tests des états d'intolerance. Bull. Soc. franç. Dermat. 42, 83 (1935).

    Google Scholar 

  • Urbach, E., u. E. Sidavaricius: Zur Kritik der Methoden der passiven Übertragung der überempfindlichkeit. Klin. Wschr. 1930, 2095.

  • Wager, O. A., and M. W. Chase: Appearance of diphtheria antitoxin following transfer of cells taken from immunized rabbits. Federat. Proc., 11, 1 (1952).

    Google Scholar 

  • Weiss, H., u. J. Tsuru: Über den Einfluß des anaphylaktischen Shocks auf das Blut. Immun. forsch. 5, 516 (1910).

    Google Scholar 

  • Woodruff, M., and B. Forman: The production of circulating antibodies by homogenats of lymphoid tissue and skin. Brit. J. Exper. Path. 31, 306 (1950).

    Google Scholar 

  • : Effect of antilymphocytic serum in suspension of lymphocytes in vitro. Nature, (Lond.) 168, 35 (1951).

    Google Scholar 

  • Yoffey, J.M.: The mammalian lymphocyte. Biol. Rev. Cambridge Philos. Sec. 25, 314 (1950).

    Google Scholar 

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  1. Hautabteilung der Poliklinik 1 in Prag 1, Prag, Tschechische

    Ladislav Polák

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Polák, L. Die Beteiligung der mesenchymalen Zellen (Lymphocyten und Monocyten) bei der Entstehung der Hautsensibilisierung der Meerschweinchen mit Dinitrochlorbenzol. Arch. klin. exp. Derm. 203, 440–453 (1956). https://doi.org/10.1007/BF00482416

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