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Die Beteiligung der mesenchymalen Zellen (Lymphocyten und Monocyten) bei der Entstehung der Hautsensibilisierung der Meerschweinchen mit Dinitrochlorbenzol

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Zusammenfassend

Im Verlaufe der Sensibilisation der Meerschweinchen steigt die RNS in der Haut und in der Leber an, dagegen nicht in der Milz; der DNS-Gehalt ändert sich in allen untersuchten Organen praktisch nicht.

Wenn auch unsere Ergebnisse, der kleinen Anzahl von Tieren wegen, nur eine beschränkte Gültigkeit haben, bestätigen sie doch unsere Ansichten über die Erhöhung der Lymphocyten in der Haut und über ihre intensivere Produktion in der Leber. Die Erhöhung der RNS in der Leber kann auch wahrscheinlich als Folge einer Aktivierung der Leber-RES-Zellen, die bei der Sensibilisierung eine wichtige Rolle in der Produktion der Antikörper respektive als Träger der Antikörpereigenschaften spielen, angesehen werden.

Daß wir keine Veränderungen der DNS in den untersuchten Organen fanden, entspricht den Angaben von Kedrovskij (1951), welcher feststellen konnte, daß die Veränderungen der DNS verhältnismäßig seltener vorkommen als die Veränderungen der RNS, die sich an den biologischen Prozessen viel mehr beteiligt.

Selbstverständlich müssen unsere Ergebnisse an einem größeren Material bestätigt und insbesondere die Rolle der Nucleinsäuren bei der ekzematösen Sensibilisation eingehender analysiert werden. Auch die reflektorische Steuerung des Nucleinsäure-Stoffwechsels in der Haut und anderen Geweben beim Sensibilisationsprozeß sollte noch Gegenstand weiterer Forschungen werden.

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  1. Hautabteilung der Poliklinik 1 in Prag 1, Prag, Tschechische

    Ladislav Polák

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Polák, L. Die Beteiligung der mesenchymalen Zellen (Lymphocyten und Monocyten) bei der Entstehung der Hautsensibilisierung der Meerschweinchen mit Dinitrochlorbenzol. Arch. klin. exp. Derm. 203, 440–453 (1956). https://doi.org/10.1007/BF00482416

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